자료유형  

 학위논문

Control Number  

0017163652

International Standard Book Number  

9798384456735

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Segura-Roman, Ashley.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Berkeley., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

60 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-04, Section: B.

General Note  

Includes supplementary digital materials.

General Note  

Advisor: Zoncu, Roberto.

Dissertation Note  

Thesis (Ph.D.)--University of California, Berkeley, 2024.

Summary, Etc.  

요약The correct function of organisms ranging from bacteria to humans critically depends on the cells' ability to rapidly change its metabolism through dedicated signaling cascades that transduce signals present in the surrounding environment. Two examples of these signaling cascades: mechanistic target of rapamycin complex 1 (mTORC1) and cAMP-dependent protein kinase A (PKA) work in tangent with cellular processes like autophagy to maintain cellular homeostasis. The two-way regulation between mTORC1 and autophagy is clear but the relationship between autophagy and PKA is more complex. Here I will focus on this complex interaction and propose a model where autophagy is regulating the PKA holoenzyme but also becomes a signaling scaffold for AKAP11-bound PKA. Furthermore, I also talk about the implications of our findings in the context of schizophrenia and bipolar disorder.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Molecular biology.

Index Term-Uncontrolled  

Mechanistic target of rapamycin complex 1

Index Term-Uncontrolled  

Protein kinase A

Index Term-Uncontrolled  

Bipolar disorder

Index Term-Uncontrolled  

Schizophrenia disorder

Added Entry-Corporate Name  

University of California, Berkeley Molecular & Cell Biology

Host Item Entry  

Dissertations Abstracts International. 86-04B.

Electronic Location and Access  

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Control Number  

joongbu:658628