자료유형  

 학위논문

Control Number  

0017160656

International Standard Book Number  

9798382346526

Dewey Decimal Classification Number  

616

Main Entry-Personal Name  

Hamilton, Stevie.

Publication, Distribution, etc. (Imprint  

[S.l.] : Columbia University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

371 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

General Note  

Advisor: Polleux, Franck.

Dissertation Note  

Thesis (Ph.D.)--Columbia University, 2024.

Summary, Etc.  

요약The AMP-activated protein kinase (AMPK) is a master metabolic regulator and energy sensor that has been extensively studied in the context of cancer and metabolic disorders. However, its role in neuronal function and morphology remains largely unexplored. This dissertation aims to bridge this gap by investigating the roles of AMPK in maintaining axon homeostasis and regulating mitochondrial morphology in neurons. By identifying novel regulators of AMPK across different cellular compartments, this thesis sheds light on the multifaceted functions of AMPK in shaping neuronal and mitochondrial architecture. The dissertation is organized into five chapters. Chapter 1 provides a brief background on AMPK, its activation mechanisms, and the downstream pathways it regulates. Chapter 2 introduces with-no-lysine kinase (WNK), a novel axon morphogenic kinase with dual roles in terminal axon branch development and maintenance in mature axons. Chapter 3 investigates the role of AMPK in mediating the loss-of-WNK axonal phenotypes, revealing a critical link between AMPK and axonal integrity. Chapter 4 shifts focus to the mitochondrial, characterizing mitochondrial fission regulator 1-like (MTFR1L) as a novel AMPK-activated protein that regulates mitochondrial morphology. Finally, Chapter 5 explores the role of AMPK in mediating activity-dependent mitochondrial morphology in hippocampal CA1 neurons, highlighting the dynamic interplay between neuronal activity and mitochondrial dynamics. Collectively, these findings provide novel insights into the multifaceted roles of AMPK in neuronal development, degeneration, and organelle regulation, underscoring the importance of this master kinase in maintaining neuronal health and homeostasis.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Molecular biology.

Subject Added Entry-Topical Term  

Biochemistry.

Index Term-Uncontrolled  

Energy sensor

Index Term-Uncontrolled  

Axon degeneration

Index Term-Uncontrolled  

Axon development

Index Term-Uncontrolled  

Mitochondrial morphology

Index Term-Uncontrolled  

Wallerian degeneration

Added Entry-Corporate Name  

Columbia University Neurobiology and Behavior

Host Item Entry  

Dissertations Abstracts International. 85-11B.

Electronic Location and Access  

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Control Number  

joongbu:658573