Material Type  

 학위논문

 

0017162536

Date and Time of Latest Transaction  

20250211152023

ISBN  

9798384019022

DDC  

620.8

Author  

Elisha, Guy.

Title/Author  

Novel Frameworks for Understanding Esophageal Mechanophysiology.

Publish Info  

[S.l.] : Northwestern University., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

265 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

General Note  

Advisor: Patankar, Neelesh A.

학위논문주기  

Thesis (Ph.D.)--Northwestern University, 2024.

Abstracts/Etc  

요약Esophageal motility disorders (EMDs) affect a significant portion of the population, yet their mechanisms and progression remain poorly understood, impeding the development of effective treatments. By establishing a comprehensive, mechanics-based understanding of esophageal functions and dysfunctions, we can advance classification and enhance diagnostic capabilities of EMDs. This thesis proposes two novel frameworks to analyze clinical observations and reveal the complex interactions within esophageal physiology. The aim of this work is to pioneer a new area of investigation in esophagology that is based on mechanophysiology. The first framework, termed the Pressure-Cross-Sectional Area (P-CSA) Analysis, is inspired by cardiovascular literature, where pressure-volume (P-V) hysteresis of the left ventricle is used to evaluate cardiac performance. Analogous to the construction of P-V loops in cardiac physiology, the P-CSA framework involves recording and plotting the pressure inside the esophagus and lumen area of the esophagus throughout an esophageal contractile cycle. By extending the principles used for the heart to esophageal physiology, the goal of this framework is to evaluate, quantify, and characterize normal and abnormal esophageal performance. The second framework addresses the underlying mechanisms of EMDs, which are neurologically mediated mechanical dysfunctions. An understanding of how neurological disorders lead to mechanical dysfunctions of the esophagus requires knowledge of the neural circuit of the enteric nervous system. Historically, this has been elusive. Through an organ-scale neuromechanical model, this framework reveals how aberrant neural circuitry influences esophageal contraction patterns, providing insights crucial for the development of targeted pharmacological interventions. This dissertation lays the foundation for a novel approach in esophagology, integrating mechanophysiological principles to develop the first mechanics-guided disease classification and diagnostic protocol for EMDs. By bridging the gap between clinical observations and mechanistic understanding, the frameworks presented in this thesis pave the way for effective, mechanically and neurologically focused diagnostic and treatment strategies.

Subject Added Entry-Topical Term  

Biomechanics.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Mechanical engineering.

Index Term-Uncontrolled  

Esophagus

Index Term-Uncontrolled  

Mechanophysiology

Index Term-Uncontrolled  

Neuromechanics

Index Term-Uncontrolled  

Pressure-area hysteresis

Index Term-Uncontrolled  

Reduced order model

Added Entry-Corporate Name  

Northwestern University Mechanical Engineering

Host Item Entry  

Dissertations Abstracts International. 86-02B.

Electronic Location and Access  

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Control Number  

joongbu:658359