자료유형  

 학위논문

Control Number  

0017160103

International Standard Book Number  

9798384102465

Dewey Decimal Classification Number  

157

Main Entry-Personal Name  

Nakhla, Marina Zaher.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, San Diego., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

141 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Zlatar, Zvinka Z.;Schiehser, Dawn M.

Dissertation Note  

Thesis (Ph.D.)--University of California, San Diego, 2024.

Summary, Etc.  

요약Older adults, including Non-Hispanic Whites (NHWs), Hispanics/Latinos, and those with neurodegenerative diseases (e.g., Parkinson's Disease: PD), are at risk for dementia. Subjective cognitive decline (SCD; perceived cognitive difficulties) may be an early risk marker of dementia. However, its neural correlates and utility to predict concurrent objective cognition across these different risk groups remain understudied. This 3-paper dissertation investigated associations of SCD with concurrent objective cognition across older adults at risk for dementia: 1) mostly NHWs (87% Caucasian) (age= 72.90), 2) Hispanics/Latinos (age= 73.97) versus NHWs (age= 71.81), and 3) PD (age= 67.56). Study 2 augmented Study 1 by examining ethnic differences in SCD reporting between NHWs and Hispanics/Latinos, while Study 3 expanded findings to neurodegenerative disease. Archival data was used from the UCSD WISE Lab, Shiley Marcos Alzheimer's Disease Research Center, and VA San Diego Healthcare System.Study 1 (Nakhla et al., 2024) investigated the relationship of self-reported SCD with objective cognition and cerebral blood flow (CBF) in a cognitively normal sample (N=52) with varying stroke risk status. Greater SCD severity was significantly associated with lower memory and entorhinal CBF in the total sample and in those with higher stroke risk (n=31). Study 2 (Nakhla et al., 2021) investigated if the relationship between self-reported SCD and objective cognition varies as a function of ethnicity [Hispanics/Latinos (N= 35) vs NHWs (N= 48)]. Higher self-reported SCD was associated with lower global cognition in Hispanics/Latinos, but not in NHWs. Study 3 (Nakhla et al., 2021) investigated the relationship between informant-reported SCD and objective cognition in a confirmed neurodegenerative disease sample, i.e., PD, (N= 139). Higher informant-reported SCD was significantly associated with poorer objective cognition (attention, learning, delayed recall, executive function).Collectively, these studies contributed to the literature by further characterizing SCD in three different and understudied older adult samples at risk for dementia: mostly NHWs, Hispanics/Latinos, and neurodegenerative disease (i.e., PD). Findings inform clinical practice by advancing our understanding of how SCD relates to objective cognition in different samples and provide evidence that SCD is related to early risk markers of dementia.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Psychobiology.

Subject Added Entry-Topical Term  

Aging.

Subject Added Entry-Topical Term  

Cognitive psychology.

Index Term-Uncontrolled  

Alzheimer's disease

Index Term-Uncontrolled  

Memory

Index Term-Uncontrolled  

Neuropsychology

Index Term-Uncontrolled  

Objective cognition

Index Term-Uncontrolled  

Subjective cognitive decline

Added Entry-Corporate Name  

University of California, San Diego Clinical Psychology (Joint Doctoral with SDSU)

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:658138