자료유형  

 학위논문

Control Number  

0017161508

International Standard Book Number  

9798382230863

Dewey Decimal Classification Number  

612

Main Entry-Personal Name  

Malachia Yvonne Hoover.

Publication, Distribution, etc. (Imprint  

[S.l.] : Stanford University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

201 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

General Note  

Advisor: Longaker, Michael.

Dissertation Note  

Thesis (Ph.D.)--Stanford University, 2024.

Summary, Etc.  

요약The intervertebral disc (IVD), also known as the spinal disc, undergoes accelerated degeneration compared to other connective tissues, leading to intervertebral disc degeneration. Addressing this challenge requires effective treatments capable of reversing fibrocartilage damage caused by factors such as age and injury. Tissue-resident stem cells hold promise for IVD treatment due to their self-renewal and differentiation properties. In this dissertation, I will discuss our efforts to identify novel regulators of spinal skeletal stem cell (SSC) differentiation and their role in regenerating IVD tissue in response to injury. Additionally, I will outline a protocol we developed for isolating and functionally assessing human SSCs from various cell and tissue sources. Our basic and preclinical findings lay the foundation for innovative stem cell-based therapies targeting IVD degeneration and other related disorders.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Molecular biology.

Index Term-Uncontrolled  

Skeletal stem cell

Index Term-Uncontrolled  

Intervertebral disc

Index Term-Uncontrolled  

IVD treatment

Index Term-Uncontrolled  

IVD degeneration

Added Entry-Corporate Name  

Stanford University.

Host Item Entry  

Dissertations Abstracts International. 85-11B.

Electronic Location and Access  

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Control Number  

joongbu:657712