Material Type  

 학위논문

 

0017161508

Date and Time of Latest Transaction  

20250211151405

ISBN  

9798382230863

DDC  

612

Author  

Malachia Yvonne Hoover.

Title/Author  

Navigating the Spinal Skeletal Stem Cell Microenvironment: Insights for Targeted Tissue Regeneration.

Publish Info  

[S.l.] : Stanford University., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

201 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

General Note  

Advisor: Longaker, Michael.

학위논문주기  

Thesis (Ph.D.)--Stanford University, 2024.

Abstracts/Etc  

요약The intervertebral disc (IVD), also known as the spinal disc, undergoes accelerated degeneration compared to other connective tissues, leading to intervertebral disc degeneration. Addressing this challenge requires effective treatments capable of reversing fibrocartilage damage caused by factors such as age and injury. Tissue-resident stem cells hold promise for IVD treatment due to their self-renewal and differentiation properties. In this dissertation, I will discuss our efforts to identify novel regulators of spinal skeletal stem cell (SSC) differentiation and their role in regenerating IVD tissue in response to injury. Additionally, I will outline a protocol we developed for isolating and functionally assessing human SSCs from various cell and tissue sources. Our basic and preclinical findings lay the foundation for innovative stem cell-based therapies targeting IVD degeneration and other related disorders.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Molecular biology.

Index Term-Uncontrolled  

Skeletal stem cell

Index Term-Uncontrolled  

Intervertebral disc

Index Term-Uncontrolled  

IVD treatment

Index Term-Uncontrolled  

IVD degeneration

Added Entry-Corporate Name  

Stanford University.

Host Item Entry  

Dissertations Abstracts International. 85-11B.

Electronic Location and Access  

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Control Number  

joongbu:657712