자료유형  

 학위논문

Control Number  

0017161973

International Standard Book Number  

9798383280287

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Officer, Adam.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, San Diego., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

88 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

General Note  

Advisor: Tamayo, Pablo;Gutkind, J. Silvio.

Dissertation Note  

Thesis (Ph.D.)--University of California, San Diego, 2024.

Summary, Etc.  

요약Tumors evolve from normal cells due to aberrant activation or repression of cell signaling. Our understanding of how these signaling pathways affect the phenotype of the malignant cells themselves, as well as the surrounding microenvironment, is lacking. As the era of precision medicine approaches, a more holistic understanding of cancer intrinsic signaling and its effect on the epigenome of tumor cells, as well as how these tumor cells interact with surrounding normal cells, is key to unlocking novel therapeutic targets and biomarkers. Through three examples of cancer evolution and signaling I will show the value of integrative data modeling to better understand the biology of this disease.First, in the context of breast cancer progression, I developed a microenvironment modeling approach to identify several novel intercellular signaling pathways that are altered in the transition from in situ to invasive disease. Second, in uveal melanoma, a cancer caused by aberrant GNAQ signaling, I generated and integrated transcriptional and protein level datasets together to nominate p53, and other pathways, as novel downstream targets of GNAQ. And third, in the context of head and neck cancer progression, I characterized the role of YAP activation in malignant transformation and cell signaling through EGFR and mTOR.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Biomedical engineering.

Subject Added Entry-Topical Term  

Oncology.

Index Term-Uncontrolled  

Tumors

Index Term-Uncontrolled  

Cancer progression

Index Term-Uncontrolled  

Cancer evolution

Index Term-Uncontrolled  

Cell signaling

Added Entry-Corporate Name  

University of California, San Diego Bioinformatics and Systems Biology

Host Item Entry  

Dissertations Abstracts International. 86-01B.

Electronic Location and Access  

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Control Number  

joongbu:657022