자료유형  

 학위논문

Control Number  

0017163045

International Standard Book Number  

9798383691816

Dewey Decimal Classification Number  

157

Main Entry-Personal Name  

Clayton, Matthew G.

Publication, Distribution, etc. (Imprint  

[S.l.] : The University of North Carolina at Chapel Hill., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

140 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

General Note  

Advisor: Prinstein, Mitchell J.

Dissertation Note  

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.

Summary, Etc.  

요약Recent theories of adolescent suicide risk posit that teens may be uniquely vulnerable to risk for suicidal thoughts and behaviors (STB) via dysregulation of inflammatory processes that are activated as part of the body's innate immune response to acute interpersonal stress. Moreover, adolescents experience more interpersonal stressors and sensitivity to such stress alongside developmental changes that occur throughout adolescence. The three studies included in this dissertation examined stress-induced proinflammatory processes and their concurrent and prospective associations with STB in samples of adolescent girls at heightened risk for suicide. Using mixed methods, laboratory-based research designs, multiple biomarkers of inflammation were investigated - proinflammatory cytokines, genomic markers known as conserved transcription responses to adversity (CTRA), and specific mRNA indicators of monocyte abundance in the circulating blood pool. Study 1 found that reactive inflammatory cytokine expression moderated prospective effects of interpersonal stress on suicidal behavior, whereby blunted cytokine expression heightened the effects of interpersonal stress on future risk for suicidal behavior. Additionally, the findings of Study 2 suggest that baseline levels of CTRA may confer heightened prospective risk for STB over 12 months. Study 3 extended this work to examine the effect of sleep disturbances on reactive genomic inflammation, with findings suggesting that sleep quality may play a role in heightening cellular inflammatory mechanisms that are part of the immune response cascade activated in the context of stress. The three studies of this dissertation underscore the importance of future research on proximal risk factors for adolescent suicide, while giving valuable justification for current and future clinical interventions that target adaptive coping in response to acute interpersonal stress.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Mental health.

Subject Added Entry-Topical Term  

Immunology.

Index Term-Uncontrolled  

Adolescence

Index Term-Uncontrolled  

Genomics

Index Term-Uncontrolled  

Inflammation

Index Term-Uncontrolled  

Stress

Index Term-Uncontrolled  

Suicide

Added Entry-Corporate Name  

The University of North Carolina at Chapel Hill Psychology

Host Item Entry  

Dissertations Abstracts International. 86-02B.

Electronic Location and Access  

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Control Number  

joongbu:657000