자료유형  

 학위논문

Control Number  

0017161698

International Standard Book Number  

9798382775647

Dewey Decimal Classification Number  

530

Main Entry-Personal Name  

Ozturk, Sukru Furkan.

Publication, Distribution, etc. (Imprint  

[S.l.] : Harvard University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

233 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Sasselov, Dimitar.

Dissertation Note  

Thesis (Ph.D.)--Harvard University, 2024.

Summary, Etc.  

요약Essential molecules of life-amino acids, nucleic acids, and sugars-are chiral; they exist in mirror-symmetrical pairs. However, biological systems exclusively use only one form of these pairs: right-handed sugars and nucleic acids, along with left-handed amino acids. This phenomenon characterizes life as homochiral. However, the origins of this asymmetry remain elusive, and it is this long-standing mystery that we address in this thesis.The chiral-induced spin selectivity (CISS) effect has established a strong coupling between electron spin and molecular chirality and this coupling paves the way for breaking the chiral molecular symmetry by spin-selective processes. Achiral magnetic surfaces, when spin-polarized, can function as chiral agents due to the CISS effect, serving as templates for the asymmetric crystallization of chiral molecules.In this thesis, we studied the spin-selective crystallization of racemic ribo-aminooxazoline (RAO), a central precursor of RNA, on magnetite surfaces-achieving homochirality in two crystallization steps. Moreover, we have shown the chirality-induced avalanche magnetization of magnetite by RAO molecules, which verifies the reciprocal nature of the effect and allows for a cooperative feedback between chiral molecules and magnetic surfaces. Finally, based on empirical evidence, we propose a pathway through which the achieved homochirality in a single chiral compound, RAO, can efficiently propagate throughout the entire prebiotic network, starting from D-nucleic acids, to L-peptides, and then to homochiral metabolites.Our results demonstrate a prebiotically plausible way of achieving systems-level homochirality from completely racemic starting materials through a process initiated by the physical environment.

Subject Added Entry-Topical Term  

Physics.

Subject Added Entry-Topical Term  

Molecular physics.

Subject Added Entry-Topical Term  

Organic chemistry.

Subject Added Entry-Topical Term  

Atomic physics.

Index Term-Uncontrolled  

Chiral-induced spin selectivity

Index Term-Uncontrolled  

Homochirality

Index Term-Uncontrolled  

Magnetite

Index Term-Uncontrolled  

Ribose-aminooxazoline

Added Entry-Corporate Name  

Harvard University Physics

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:656901