자료유형  

 학위논문

Control Number  

0017160293

International Standard Book Number  

9798381974973

Dewey Decimal Classification Number  

531

Main Entry-Personal Name  

Li, Shupeng.

Publication, Distribution, etc. (Imprint  

[S.l.] : Northwestern University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

156 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

General Note  

Advisor: Huang, Yonggang.

Dissertation Note  

Thesis (Ph.D.)--Northwestern University, 2024.

Summary, Etc.  

요약Bio-integrated electronics have captured significant attention among researchers due to their potential to revolutionize healthcare with smarter and more personalized applications, both within clinic environments and beyond. In contrast to conventional rigid and wired electronics, the emerging generation of flexible and stretchable electronics offers distinct advantages for seamless bio-integration. These include notable features such as biocompatibility, mechanical robustness, and intimate conformability to tissues. Many of these devices also incorporate wireless communication technology and fully biodegradable materials, unlocking endless possibilities for continuous health monitoring, diagnostics, and rapid therapeutic delivery.However, challenges accompany the development of such devices. The mechanical behavior must be delicately designed with regard to materials and structures to achieve robustness and conformability. More critically, these miniaturized devices must attain comparable or superior performance compared to traditional biomedical devices. They are tasked with passively measuring and quantifying a broad range of physical and chemical signals stemming from natural physiological processes, and actively stimulating and responding to these signals for precise diagnostic and targeted delivery of therapy. While some superficial signals, such as heart rate and skin temperature, can be directly collected and analyzed, others, like blood pressure and blood flow rate, present difficulties in measurement, necessitating innovative measuring strategies. Moreover, electronics equipped with therapeutic functionalities have not kept pace with the advancements in emerging sensing units.This dissertation systematically investigates multiple bio-integrated electronics through numerical and analytical methods, with the aim of providing supportive design strategies. Intuitive understandings are offered to correlate physical parameters with mechanics compliance, sensation, and actuation performance. This includes the control of buckling serpentine electronics along with the extension to electromagnetic actuation, wireless monitoring of blood pressure and microvascular blood flow, and the development of multimodal haptic actuators towards sensory substitution.First, I investigate the buckling behavior of commonly employed serpentine structures in stretchable electronics. As the size goes down, the elastic energy is significantly decreased compared to the adhesion energy between the 2D precursor and elastomeric substrate, preventing it from successfully buckling up to form the targeted 3D structures; besides, the buckling deformation may exceed the elastic or fracture limits of the material, leading to mechanical failure of the 3D structure. I examine the adhesion, elastic energy and maximum strain for three buckling states via theoretical modeling and finite element analysis and establish a phase diagram to guide the micro or nanoscale design and fabrication. Predicting and controlling buckling behaviors enable the exploration of actuating the deformation of post-buckling 3D nanostructures. However, challenges arise due to the mismatch between actuation forces and structure rigidity at micro/nanoscale. I propose strategies involving integrating current-carrying metallic or magnetic films into microscale structures to generate controlled Lorentz or magnetic forces under an external field. Quantitative modeling and scaling laws facilitate the formation of low-rigidity 3D architectures at the microscale, enabling significant, reversible, and rapid deformation through remotely controlled electromagnetic actuation.Secondly, I present strategies for wireless, continuous blood pressure measurement using a skin-mounted, non-invasive pressure sensor. Existing methods for continuous, non-invasive measurements are either wired and bulky or susceptible to artifacts. Leveraging the skin-interfaced pressure sensor, I establish a scaling law between blood pressure in the radial artery and the sensor's response through finite element analysis. Alongside separate measurements of pulse wave velocity, this sensor accommodates changes in skin properties due to drug effects, providing robust calibration methods.Thirdly, I contribute to the design of implantable thermal sensors for microvascular blood flow monitoring, particularly applicable in early and accurate thrombosis diagnosis in free tissue transfer and solid organ allotransplantation. These wireless sensors, usable across all tissues and organs, employ biodegradable materials for safe removal. While measuring temperature rather than flow velocity, I develop a theoretical model connecting the measured temperature to flow velocity. The model holds potential applications in early disease diagnosis and other microfluid flow measurements within the human body.Lastly, I contribute to the development of electromagnetic-driven multimodal haptic actuators. These actuators possess the ability to stimulate rapidly and slowly adapting mechanoreceptors with bistable and vibration modes in a fast, programmable manner - a novel feature not reported before. I establish mechanics and electromagnetic models to explore these modes under different tissue conditions and device designs, proposing a phase diagram to guide bistable design. This haptic device finds applications in social media, entertainment, and clinical therapy, providing solutions for substituting and augmenting missing sensory capabilities.

Subject Added Entry-Topical Term  

Mechanics.

Subject Added Entry-Topical Term  

Biomedical engineering.

Subject Added Entry-Topical Term  

Materials science.

Subject Added Entry-Topical Term  

Nanotechnology.

Subject Added Entry-Topical Term  

Medical imaging.

Index Term-Uncontrolled  

Solid mechanics

Index Term-Uncontrolled  

Stretchable electronics

Index Term-Uncontrolled  

Bio-integrated electronics

Index Term-Uncontrolled  

Blood pressure

Index Term-Uncontrolled  

Biomedical devices

Added Entry-Corporate Name  

Northwestern University Mechanical Engineering

Host Item Entry  

Dissertations Abstracts International. 85-10B.

Electronic Location and Access  

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Control Number  

joongbu:654622