Material Type  

 학위논문

 

0017160350

Date and Time of Latest Transaction  

20250211151002

ISBN  

9798382777665

DDC  

616

Author  

He, Lily.

Title/Author  

Molecular Tuning of Sea Anemone Stinging.

Publish Info  

[S.l.] : Harvard University., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

165 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Bellono, Nicholas.

학위논문주기  

Thesis (Ph.D.)--Harvard University, 2024.

Abstracts/Etc  

요약The judicious control of behavior in response to environmental cues is key to survival for all living creatures. We choose to study sensory transduction and behavior regulation in cnidarians like jellyfish and anemones because they present as an attractive system with decentralized nervous systems and a unique "all-or-nothing" stinging behavior. Cnidarians use specialized cells called nematocytes to shoot single-use, venom-covered barbs to envenomate prey or predators. How do different cnidarians control stinging for different purposes like predation versus defense? We previously showed that the anemone Nematostella vectensis uses a specialized voltage-gated calcium (CaV) channel to trigger stinging in response to synergistic prey-derived chemicals and touch (Weir et al., 2020). Here we use experiments and theory to reveal that stinging behavior is suited to distinct ecological niches. While the burrowing anemone Nematostella uses uniquely strong CaV inactivation for precise control of predatory stinging, the related anemone Exaiptasia diaphana, which inhabits exposed environments to support photosynthetic endosymbionts, stings indiscriminately for self-defense. Consistent with their indiscriminate stinging behavior, Exaiptasia nematocytes express a CaV splice variant that confers weak CaV inactivation. Chimeric analyses of jellyfish and anemone CaVs revealed that differences in inactivation are mediated by the CaVβ subunit N-terminus. These findings reveal a molecular control mechanism for cnidarian stinging and demonstrate how evolutionary tuning of ion channel structure suits distinct signal processing and behavior.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Evolution & development.

Index Term-Uncontrolled  

Adaptation

Index Term-Uncontrolled  

Calcium channel

Index Term-Uncontrolled  

Cnidarian

Index Term-Uncontrolled  

Inactivation

Index Term-Uncontrolled  

Stinging

Added Entry-Corporate Name  

Harvard University Medical Sciences

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:654603