자료유형  

 학위논문

Control Number  

0017160804

International Standard Book Number  

9798382834894

Dewey Decimal Classification Number  

616

Main Entry-Personal Name  

Ortiz, Elelbin A.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pennsylvania., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

107 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Granato, Michael.

Dissertation Note  

Thesis (Ph.D.)--University of Pennsylvania, 2024.

Summary, Etc.  

요약Animals have a challenging task while navigating their environment: they must continuously ignore irrelevant information while responding to important environmental cues. To achieve this task, animals must establish mechanisms to regulate their behavior in response to their environments. An approach animals can use is to use characteristics of a stimulus, such as the intensity, to determine if a behavioral response is required. The acoustic startle response is a highly conserved defensive behavior during which animals respond to sudden sounds if the sound intensity surpasses a threshold. Regulation of this threshold has two components: establishment of an innate baseline threshold during development and short-term modifications to the threshold based on acute changes in the environment. Dysregulation of the acoustic startle threshold is associated with several human neurodevelopmental and neuropsychiatric disorders. Despite its importance, the genetic mechanisms that underlie establishment of the startle threshold, and how these mechanisms overlap or diverge between establishment and acute regulation are poorly understood. Using a mutant zebrafish line (escapist), I identified a single base pair mutation that is tightly linked to an abnormally lowered baseline acoustic startle threshold. Using the mutation as a genetic tool to identify escapist mutants, I identify that escapist larvae exhibit changes in baseline responses to acoustic and visual stimuli. In contrast, further characterization of short-term regulation of acoustic and visual behavior thresholds identifies that acute regulation remains intact in escapist larvae compared to wildtype siblings. My work highlights the existence of nonoverlapping regulators of baseline and acute behavioral thresholds and provides an entry point to study the genetic and cellular mechanisms underlying the development of innate behavioral thresholds.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Genetics.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Acoustics.

Index Term-Uncontrolled  

Acoustic sensitivity

Index Term-Uncontrolled  

Behavioral thresholds

Index Term-Uncontrolled  

Hypersensitivity

Index Term-Uncontrolled  

Zebrafish

Index Term-Uncontrolled  

Escapist

Added Entry-Corporate Name  

University of Pennsylvania Neuroscience

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:653780