자료유형  

 학위논문

Control Number  

0016932917

International Standard Book Number  

9798379866372

Dewey Decimal Classification Number  

589

Main Entry-Personal Name  

Jones, Thane Robinson.

Publication, Distribution, etc. (Imprint  

[S.l.] : North Carolina State University., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(128 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

General Note  

Advisor: Bruno-Barcena, Jose;Pierce, Joshua G.

Dissertation Note  

Thesis (Ph.D.)--North Carolina State University, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약There is a recognized need for the constant development of novel antibiotic scaffolds to combat pathogenic drug-resistant bacteria. Abyssomicin C is a marine natural product isolated in 2004 from the Sea of Japan which displays activity against MRSA (MIC = 4 μg/mL) and VRSA (MIC = 14 μg/mL). Abyssomicin C is the first compound known to inhibit p-aminobenzoic acid production in bacterial folate biosynthesis, making it a potential lead for the study of new antibacterial agents targeting drug-resistant bacteria. However, the SAR of the abyssomicin scaffold is limited, largely due to the lack of known structural derivatives despite several published syntheses. Abyssomicin C is an exciting synthetic target due to its complex molecular structure. The CG-terpenoid bears 8 stereogenic centers, 5 of which are contiguous throughout a bicyclic spirotetronate core at the base of a 14-membered medium-sized ring. Herein we describe efforts toward a practical, scalable synthetic route to abyssomicin C and potential derivates in order to probe its exciting potential antibacterial lead.

Subject Added Entry-Topical Term  

Fungi.

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Cytotoxicity.

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Biosynthesis.

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Chemical reactions.

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Vitamin B.

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Bacteria.

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Staphylococcus infections.

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Chemistry.

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Hydration.

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Biological activity.

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Lithium.

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Drug resistance.

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Aqueous solutions.

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Construction.

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Oxidation.

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Antibiotics.

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Carbon.

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Bacterial infections.

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Design.

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Alcohol.

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Natural products.

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Metabolites.

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Cellular biology.

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Civil engineering.

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Organic chemistry.

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Pathology.

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Pharmaceutical sciences.

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Pharmacology.

Added Entry-Corporate Name  

North Carolina State University.

Host Item Entry  

Dissertations Abstracts International. 85-01B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:643903