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Development and Application of a Quadrupole Time-of-Flight Mass Spectrometer for the Analysis of Synthetic Polymers, Proteins, and Protein Complexes- [electronic resource]
Development and Application of a Quadrupole Time-of-Flight Mass Spectrometer for the Analysis of Synthetic Polymers, Proteins, and Protein Complexes- [electronic resource]
- 자료유형
- 학위논문
- Control Number
- 0016932843
- International Standard Book Number
- 9798379849023
- Dewey Decimal Classification Number
- 600
- Main Entry-Personal Name
- Bhanot, Jay Sharma.
- Publication, Distribution, etc. (Imprint
- [S.l.] : Purdue University., 2022
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2022
- Physical Description
- 1 online resource(176 p.)
- General Note
- Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
- General Note
- Advisor: McLuckey, Scott A.
- Dissertation Note
- Thesis (Ph.D.)--Purdue University, 2022.
- Restrictions on Access Note
- This item must not be sold to any third party vendors.
- Summary, Etc.
- 요약In the last thirty years, ion/ion reactions have been developed and applied to answer increasingly difficult analytical problems across a variety of industries. This requires the constant development of instrumentation that can enable work with the analyte modalities of highest impact. Such analytes have become increasingly high in molecular weight precluding many analysis techniques, such as mass spectrometry. In this work, a commercial quadrupole time-of-flight mass spectrometer was modified and adapted to support the analysis of high-mass bio-ions using ion/ion reactions. Using a highly modified instrument, novel capabilities and theory were developed around the analysis and detection of ions with m/z ratios as high as 400,000 m/zand 2.2 mDa. These capabilities enabled and benefitted the analysis of polymers, peptides, and proteins and in this work was demonstrated as an effective instrument a variety of applications. By using data generated on this apparatus, the rapid characterization of PS 80 samples using MATLAB programs to aide in peak identification, native ion parking, and novel ETD reagents were completed. Given the expanding role of biological systems in all areas of science, the development, characterization, and utilization of a highly versatile mass spectrometer is described herein.
- Subject Added Entry-Topical Term
- Polymers.
- Subject Added Entry-Topical Term
- Mass spectrometry.
- Subject Added Entry-Topical Term
- Electrodes.
- Subject Added Entry-Topical Term
- Blood vessels.
- Subject Added Entry-Topical Term
- Oxidation.
- Subject Added Entry-Topical Term
- Charged particles.
- Subject Added Entry-Topical Term
- Ions.
- Subject Added Entry-Topical Term
- Solvents.
- Subject Added Entry-Topical Term
- Electric fields.
- Subject Added Entry-Topical Term
- Fatty acids.
- Subject Added Entry-Topical Term
- Molecular weight.
- Subject Added Entry-Topical Term
- Scientific imaging.
- Subject Added Entry-Topical Term
- Chromatography.
- Subject Added Entry-Topical Term
- Electric currents.
- Subject Added Entry-Topical Term
- Polypeptides.
- Subject Added Entry-Topical Term
- Analytical chemistry.
- Subject Added Entry-Topical Term
- Atomic physics.
- Subject Added Entry-Topical Term
- Chemistry.
- Subject Added Entry-Topical Term
- Electromagnetics.
- Subject Added Entry-Topical Term
- Physics.
- Subject Added Entry-Topical Term
- Polymer chemistry.
- Added Entry-Corporate Name
- Purdue University.
- Host Item Entry
- Dissertations Abstracts International. 85-01B.
- Host Item Entry
- Dissertation Abstract International
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:643621
