Material Type  

 학위논문

 

0016932523

Date and Time of Latest Transaction  

20240214100509

ISBN  

9798379684488

DDC  

759.3

Author  

Ulcickas, James RW.

Title/Author  

Light and Chemistry at the Interface of Theory and Experiment - [electronic resource]

Publish Info  

[S.l.] : Purdue University., 2020

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2020

Material Info  

1 online resource(146 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

General Note  

Advisor: Simpson, Garth.

학위논문주기  

Thesis (Ph.D.)--Purdue University, 2020.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Abstracts/Etc  

요약Optics are a powerful probe of chemical structure that can often be linked to theoretical predictions, providing robustness as a measurement tool. Not only do optical interactions like second harmonic generation (SHG), single and two-photon excited fluorescence (TPEF), and infrared absorption provide chemical specificity at the molecular and macromolecular scale, but the ability to image enables mapping heterogeneous behavior across complex systems such as biological tissue. This thesis will discuss nonlinear and linear optics, leveraging theoretical predictions to provide frameworks for interpreting analytical measurement. In turn, the causal mechanistic understanding provided by these frameworks will enable structurally specific quantitative tools with a special emphasis on application in biological imaging. The thesis will begin with an introduction to 2nd order nonlinear optics and the polarization analysis thereof, covering both the Jones framework for polarization analysis and the design of experiment. Novel experimental architectures aimed at reducing 1/f noise in polarization analysis will be discussed, leveraging both rapid modulation in time through electro-optic modulators (Chapter 2), as well as fixed-optic spatial modulation approaches (Chapter 3). In addition, challenges in polarization-dependent imaging within turbid systems will be addressed with the discussion of a theoretical framework to model SHG occurring from unpolarized light (Chapter 4). The application of this framework to thick tissue imaging for analysis of collagen local structure can provide a method for characterizing changes in tissue morphology associated with some common cancers (Chapter 5). In addition to discussion of nonlinear optical phenomena, a novel mechanism for electric dipole allowed fluorescence-detected circular dichroism will be introduced (Chapter 6). Tackling challenges associated with label-free chemically specific imaging, the construction of a novel infrared hyperspectral microscope for chemical classification in complex mixtures will be presented (Chapter 7). The thesis will conclude with a discussion of the inherent disadvantages in taking the traditional paradigm of modeling and measuring chemistry separately and provide the multi-agent consensus equilibrium (MACE) framework as an alternative to the classic meet-in-the-middle approach (Chapter 8). Spanning topics from pure theoretical descriptions of light-matter interaction to full experimental work, this thesis aims to unify these two fronts.

Subject Added Entry-Topical Term  

Collagen.

Subject Added Entry-Topical Term  

Signal to noise ratio.

Subject Added Entry-Topical Term  

Lasers.

Subject Added Entry-Topical Term  

Symmetry.

Subject Added Entry-Topical Term  

Microscopy.

Subject Added Entry-Topical Term  

Labeling.

Subject Added Entry-Topical Term  

Maps.

Subject Added Entry-Topical Term  

Chemistry.

Subject Added Entry-Topical Term  

Digitization.

Subject Added Entry-Topical Term  

Optics.

Added Entry-Corporate Name  

Purdue University.

Host Item Entry  

Dissertations Abstracts International. 84-12B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

소장사항  

202402 2024

Control Number  

joongbu:642985