Material Type  

 학위논문

 

0016933764

Date and Time of Latest Transaction  

20240214101334

ISBN  

9798380263566

DDC  

658

Author  

Vincent, Augusta Marie.

Title/Author  

Investigating the Effects of Dopaminergic Medication and Parkinsons Disease State on Neural Activation in the Left Ventral Striatum - [electronic resource]

Publish Info  

[S.l.] : University of Pittsburgh., 2023

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Material Info  

1 online resource(30 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

General Note  

Advisor: Rottman, Benjamin;Calabro, Finnegan;Fiez, Julie.

학위논문주기  

Thesis (M.Sc.)--University of Pittsburgh, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Abstracts/Etc  

요약Outcome processing is a crucial way in which we learn from our choices and navigate our environments. Neural signals of outcome processing are typically understood to depend on dopamine transmission involving the basal ganglia. However, causal relationships between the observed hemodynamic signal in human neuroimaging studies of outcome processing and the presence of dopamine-mediated outcome signals can only be examined via neuropsychological methods. Parkinson's disease, which results in depleted dopamine and thus diminished dopamine signaling in the basal ganglia, provides an excellent neuropsychological opportunity to understand the causal relationships between dopamine signaling and hemodynamic changes related to outcome processing in the striatum. This study investigates how Parkinson's disease and dopaminergic medication affect hemodynamic responses associated with a guessing task involving monetary gain and loss outcomes. The estimated hemodynamic responses in the left ventral striatum of 16 participants with Parkinson's disease, on and off levodopa/carbidopa medication, and 10 controls are compared for reward and punishment outcomes, using an ANOVA-based analysis approach. No medication or group effects were observed in any contrast (all p .05). These null results are reckoned with in the context of existing literature surrounding dopamine and hemodynamic signals in the basal ganglia.

Subject Added Entry-Topical Term  

Neurobiology.

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Behavior.

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Software.

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Memory.

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Brain research.

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Neurosciences.

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Neuropsychology.

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Older people.

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Cognitive ability.

Subject Added Entry-Topical Term  

Feedback.

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Patients.

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Data integrity.

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Dopamine.

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Parkinsons disease.

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Blood pressure.

Subject Added Entry-Topical Term  

Medical research.

Subject Added Entry-Topical Term  

Statistical power.

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Hemodynamics.

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Mental depression.

Subject Added Entry-Topical Term  

Education.

Subject Added Entry-Topical Term  

Movement disorders.

Subject Added Entry-Topical Term  

Aging.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Cognitive psychology.

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Gerontology.

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Medicine.

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Mental health.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Psychology.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-03B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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소장사항  

202402 2024

Control Number  

joongbu:641457