자료유형  

 학위논문

Control Number  

0016933764

International Standard Book Number  

9798380263566

Dewey Decimal Classification Number  

658

Main Entry-Personal Name  

Vincent, Augusta Marie.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pittsburgh., 2023

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2023

Physical Description  

1 online resource(30 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

General Note  

Advisor: Rottman, Benjamin;Calabro, Finnegan;Fiez, Julie.

Dissertation Note  

Thesis (M.Sc.)--University of Pittsburgh, 2023.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Outcome processing is a crucial way in which we learn from our choices and navigate our environments. Neural signals of outcome processing are typically understood to depend on dopamine transmission involving the basal ganglia. However, causal relationships between the observed hemodynamic signal in human neuroimaging studies of outcome processing and the presence of dopamine-mediated outcome signals can only be examined via neuropsychological methods. Parkinson's disease, which results in depleted dopamine and thus diminished dopamine signaling in the basal ganglia, provides an excellent neuropsychological opportunity to understand the causal relationships between dopamine signaling and hemodynamic changes related to outcome processing in the striatum. This study investigates how Parkinson's disease and dopaminergic medication affect hemodynamic responses associated with a guessing task involving monetary gain and loss outcomes. The estimated hemodynamic responses in the left ventral striatum of 16 participants with Parkinson's disease, on and off levodopa/carbidopa medication, and 10 controls are compared for reward and punishment outcomes, using an ANOVA-based analysis approach. No medication or group effects were observed in any contrast (all p .05). These null results are reckoned with in the context of existing literature surrounding dopamine and hemodynamic signals in the basal ganglia.

Subject Added Entry-Topical Term  

Neurobiology.

Subject Added Entry-Topical Term  

Behavior.

Subject Added Entry-Topical Term  

Software.

Subject Added Entry-Topical Term  

Memory.

Subject Added Entry-Topical Term  

Brain research.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Neuropsychology.

Subject Added Entry-Topical Term  

Older people.

Subject Added Entry-Topical Term  

Cognitive ability.

Subject Added Entry-Topical Term  

Feedback.

Subject Added Entry-Topical Term  

Patients.

Subject Added Entry-Topical Term  

Data integrity.

Subject Added Entry-Topical Term  

Dopamine.

Subject Added Entry-Topical Term  

Parkinsons disease.

Subject Added Entry-Topical Term  

Blood pressure.

Subject Added Entry-Topical Term  

Medical research.

Subject Added Entry-Topical Term  

Statistical power.

Subject Added Entry-Topical Term  

Hemodynamics.

Subject Added Entry-Topical Term  

Mental depression.

Subject Added Entry-Topical Term  

Education.

Subject Added Entry-Topical Term  

Movement disorders.

Subject Added Entry-Topical Term  

Aging.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Cognitive psychology.

Subject Added Entry-Topical Term  

Gerontology.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Mental health.

Subject Added Entry-Topical Term  

Physiology.

Subject Added Entry-Topical Term  

Psychology.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-03B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:641457