자료유형  

 학위논문

Control Number  

0016933758

International Standard Book Number  

9798380263825

Dewey Decimal Classification Number  

600

Main Entry-Personal Name  

Wells, Alexandra Isabella.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pittsburgh., 2022

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2022

Physical Description  

1 online resource(251 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

General Note  

Advisor: Bakkenist, Christopher;Dermody, Terence;Hand, Timothy;Williams, John;Coyne, Carolyn.

Dissertation Note  

Thesis (Ph.D.)--University of Pittsburgh, 2022.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Enterovirus infections are major sources of disease in humans. Echoviruses are a major subtype of enteroviruses and are especially devastating to neonates and young children. Despite the number of infections and potential adverse outcomes, the basic determinants of pathogenesis for echoviruses is poorly understood. This dissertation describes the identification of the neonatal Fc receptor (FcRn) as the entry receptor for echoviruses and the subsequent development of newin vivomodels that fully recapitulate echovirus disease as well as establish the role of interferons during echovirus infections. Collectively, these studies show (1) that human FcRn is the entry receptor for echoviruses, (2) that human FcRn and type I interferons mediate infection in the liver, (3) that type I and III interferons play differential roles in infection of the gastrointestinal tract and dissemination to other tissues, (4) the meninges of the brain are the main target of echovirus infection and (5) that the host interferon stimulated genes that target enteroviruses function in pan-enterovirus- and enterovirus-species specific manners.

Subject Added Entry-Topical Term  

Infections.

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Pathogens.

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Binding sites.

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Cytokines.

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Immunology.

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Brain.

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Apoptosis.

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Pediatrics.

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Blood-brain barrier.

Subject Added Entry-Topical Term  

Feces.

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Liver.

Subject Added Entry-Topical Term  

Permeability.

Subject Added Entry-Topical Term  

Immune system.

Subject Added Entry-Topical Term  

Epidemics.

Subject Added Entry-Topical Term  

Endothelium.

Subject Added Entry-Topical Term  

Chromosomes.

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Defense mechanisms.

Subject Added Entry-Topical Term  

Viruses.

Subject Added Entry-Topical Term  

Viral infections.

Subject Added Entry-Topical Term  

Stem cells.

Subject Added Entry-Topical Term  

Microorganisms.

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Interferon.

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Human body.

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Cellular biology.

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Epidemiology.

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Genetics.

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Medicine.

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Microbiology.

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Pharmaceutical sciences.

Subject Added Entry-Topical Term  

Virology.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-03B.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:641298