자료유형  

 학위논문

Control Number  

0016933741

International Standard Book Number  

9798380262576

Dewey Decimal Classification Number  

963

Main Entry-Personal Name  

McKune, Molly.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pittsburgh., 2021

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2021

Physical Description  

1 online resource(60 p.)

General Note  

Source: Dissertations Abstracts International, Volume: 85-03, Section: A.

General Note  

Advisor: Carlson, Jenna C.;Buchanich, Jeanine;Youk, Ada;Costacou, Tina.

Dissertation Note  

Thesis (M.Sc.)--University of Pittsburgh, 2021.

Restrictions on Access Note  

This item must not be sold to any third party vendors.

Summary, Etc.  

요약Background: Previous research shows an association between higher BMI and higher cardiovascular disease (CVD) risk, as well as an association between poor sleep quality and higher CVD risk, but minimal research has been conducted in this area with Samoan adults. Samoan adults have a higher BMI than average, partially due to a variant found in their CREBRF (CREB 3 regulatory factor) gene. Due to genetic tendency to have higher BMI, it is imperative to identify factors that can mitigate the impact of high BMI on CVD risk, such as sleep quality.Objective: From a cohort selected from the GWAS which identified the CREBRF genetic variant, sleep quality and CVD risk factor data was collected. This cohort is known as The Soifua Manuia (Good Health) Study. The objective of this paper is to identify sleep quality measures which mediate the relationship between BMI and CVD risk using these participants.Methods: Path Analysis, a form of structural equation modeling, was performed on 503 participants to quantify the relationship between BMI, Sleep Quality, and CVD risk, and identify statistically significant evidence of a causal pathway where sleep quality mediates the relationship between BMI and CVD risk.Results: Three path analyses were found to be significant. Sleep disordered breathing (AHI 3%) was found to mediate the relationship between BMI and both HDL cholesterol levels and diastolic blood pressure (p 0.05). Snoring volume was found to mediate the relationship between BMI and HDL cholesterol (p 0.2). In all significant models, an improvement in the sleep quality measure was associated with an improvement in CVD risk factor on average.Conclusions: The data preliminarily shows that improvements in sleep disordered breathing and snoring volume could help mitigate the impact of BMI on HDL cholesterol and diastolic blood pressure. These data present evidence that many Samoan adults have some form of sleep disordered breathing and undiagnosed sleep apnea. The public health significance of these results is to have identified compelling evidence of the need for a public health intervention in Samoan adults to diagnose and treat sleep apnea to improve sleep quality.

Subject Added Entry-Topical Term  

Triglycerides.

Subject Added Entry-Topical Term  

Diabetes.

Subject Added Entry-Topical Term  

Body mass index.

Subject Added Entry-Topical Term  

Risk factors.

Subject Added Entry-Topical Term  

High density lipoprotein.

Subject Added Entry-Topical Term  

Cholesterol.

Subject Added Entry-Topical Term  

Genomes.

Subject Added Entry-Topical Term  

Genotype & phenotype.

Subject Added Entry-Topical Term  

Blood pressure.

Subject Added Entry-Topical Term  

Sleep apnea.

Subject Added Entry-Topical Term  

Cardiovascular disease.

Subject Added Entry-Topical Term  

Glucose.

Subject Added Entry-Topical Term  

Public health.

Subject Added Entry-Topical Term  

Low density lipoprotein.

Subject Added Entry-Topical Term  

Genetics.

Subject Added Entry-Topical Term  

Health sciences.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Pacific Rim studies.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 85-03A.

Host Item Entry  

Dissertation Abstract International

Electronic Location and Access  

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Control Number  

joongbu:641294