자료유형  

 단행본

Control Number  

n880724829

International Standard Book Number  

9780309297547 (paperback)

International Standard Book Number  

0309297540 (paperback)

International Standard Book Number  

9780309297554

International Standard Book Number  

0309297559

Library of Congress Call Number  

RA1224.2-.N38 2014

Dewey Decimal Classification Number  

616.4/06-23

Main Entry-Corporate Name  

National Research Council (U.S.) Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse

Physical Description  

1 online resource (xii, 51 pages) : illustrations

Summary, Etc.  

요약"Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation"--Publisher's description.

Bibliography, Etc. Note  

Includes bibliographical references.

Formatted Contents Note  

완전내용Introduction -- Review of the Environmental Protection Agency's methods for evaluating evidence on nonmonotonic dose-response relationships -- The Environmental Protection Agency's evaluation of implications of nonmonotonic dose-response relationships for current toxicity-testing strategies and risk-assessment practices.

Subject Added Entry-Topical Term  

Endocrine disrupting chemicals

Subject Added Entry-Topical Term  

Endocrine disrupting chemicals Toxicity testing

Subject Added Entry-Topical Term  

Dose-response relationship (Biochemistry)

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Endocrine toxicology

Subject Added Entry-Topical Term  

Endocrine Disruptors toxicity

Subject Added Entry-Topical Term  

Dose-Response Relationship, Drug

Subject Added Entry-Topical Term  

Evaluation Studies as Topic

Subject Added Entry-Topical Term  

Toxicity Tests

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Risk Assessment

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HEALTH & FITNESS Diseases General.

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MEDICAL Clinical Medicine.

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MEDICAL Diseases.

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MEDICAL Evidence-Based Medicine.

Subject Added Entry-Topical Term  

MEDICAL Internal Medicine.

Additional Physical Form Entry  

Also available in print Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors. Washington, D.C. : National Academies Press, 2014. 9780309297547 (OCoLC)881314288

Electronic Location and Access  

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Control Number  

joongbu:441977