자료유형  

 학위논문

Control Number  

0017160686

International Standard Book Number  

9798382321899

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Janda, Guneet Singh.

Publication, Distribution, etc. (Imprint  

[S.l.] : Yale University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

53 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

General Note  

Advisor: Ross, Joseph S.;Wallach, Joshua D.

Dissertation Note  

Thesis (M.D.)--Yale University, 2024.

Summary, Etc.  

요약The aim of this project was to evaluate the concordance among study characteristics, results, and interpretations described in preprints of clinical studies that are subsequently published in peer-reviewed journals (preprint-journal article pairs).In this cross-sectional analysis, preprints posted on medRxiv in September 2020 were identified. Four evaluators determined how many preprints were subsequently published in peer-reviewed journals as of September 2022, calculating the time from preprint posting to publication. For preprints with multiple versions, the most recent version prior to journal acceptance was selected. Preprints updated after journal acceptance were excluded. For preprint-journal article pairs describing clinical trials, observational studies, and meta-analyses that measured health-related outcomes, sample size, primary endpoints, corresponding results, and overarching conclusions were abstracted. Results from primary endpoints were only considered concordant if they contained the same information or had numerical equivalence (e.g., identical effect size estimates and 95% CIs/P-values from inferential analyses). Rates of concordance were compared between preprints and corresponding journal articles, overall and by focus on COVID-19 and journal impact factor (IF).Among 1399 preprints first posted on medRxiv in September 2020, a total of 1077 (77.0%) had been published as of September 15, 2022, a median of 6 months (IQR, 3-8 months) after preprint posting. Among the 547 preprint-journal article pairs describing clinical trials, observational studies, or meta-analyses, 293 (53.6%) were related to COVID-19. Of the 535 pairs reporting sample sizes in both sources, 462 (86.4%) were concordant; 43 (58.9%) of the 73 pairs with discordant sample sizes had larger samples in the journal publication. There were 534 pairs (97.6%) with concordant and 13 pairs (2.4%) with discordant primary end points. Among the 535 pairs with numerical results for the primary end points, 434 (81.1%) had concordant primary end point results; 66 of the 101 discordant pairs (65.3%) had effect size estimates that were in the same direction and were statistically consistent. Overall, 526 pairs (96.2%) had concordant study interpretations, including 82 of the 101 pairs (81.2%) with discordant primary end point results.Most clinical studies posted as preprints on medRxiv and subsequently published in peer-reviewed journals had concordant study characteristics, results, and final interpretations. With over three-quarters of preprints published in journals within 24 months, these results may suggest that many preprints report findings that are consistent with the final peer-reviewed publications.

Subject Added Entry-Topical Term  

Medicine.

Subject Added Entry-Topical Term  

Public health.

Subject Added Entry-Topical Term  

Information science.

Subject Added Entry-Topical Term  

Journalism.

Index Term-Uncontrolled  

COVID-19

Index Term-Uncontrolled  

Journal

Index Term-Uncontrolled  

Peer review

Index Term-Uncontrolled  

Preprints

Index Term-Uncontrolled  

Publishing

Index Term-Uncontrolled  

Articles

Added Entry-Corporate Name  

Yale University Yale School of Medicine

Host Item Entry  

Dissertations Abstracts International. 85-11B.

Electronic Location and Access  

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Control Number  

joongbu:658563