자료유형  

 학위논문

Control Number  

0017161577

International Standard Book Number  

9798382761275

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Ling Hu, Ted.

Publication, Distribution, etc. (Imprint  

[S.l.] : Northwestern University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

302 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

General Note  

Advisor: Hultquist, Judd F.

Dissertation Note  

Thesis (Ph.D.)--Northwestern University, 2024.

Summary, Etc.  

요약SARS-CoV-2, the causative agent of COVID-19, has had a devastating impact, resulting in over 7 million deaths worldwide. Like most viruses, SARS-CoV-2 has continued to evolve in order to adapt to selective pressures such as therapeutics and vaccines. These mutations have resulted in variants that demonstrate enhanced transmissibility, immune escape, or antiviral resistance. Genomic surveillance provides a framework in which to track the emergence of these mutations. We begin by outlining the genomic surveillance pipeline and address challenges and potential solutions associated with stage. Integrating these solutions, we conducted genomic surveillance to assess the association between SARS-CoV-2 clade and patient outcome over a two-year period. By the inclusion of population-level confounders, which includes sampling bias, we highlight the importance of integrating non-virological factors when examining patient risk. Furthermore, using the same approach, we examined the impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo. Using sequences collected from patients before and after remdesivir administration, we identified several positions that showed preferential diversification after remdesivir treatment, several of which were associated with enhanced viral fitness. Taken together, our studies highlight the significant impact of SARS-CoV-2 mutations on disease dynamics as well as therapeutic interventions and emphasizes the necessity of using an integrative modeling approach to assess the impact of viral mutations. These findings underscore the ongoing evolution of the virus and the critical role of genomic surveillance in informing public health interventions and treatment strategies.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Public health.

Subject Added Entry-Topical Term  

Epidemiology.

Subject Added Entry-Topical Term  

Genetics.

Index Term-Uncontrolled  

Antiviral resistance

Index Term-Uncontrolled  

Genomic surveillance

Index Term-Uncontrolled  

Remdesivir

Index Term-Uncontrolled  

Immune escape

Added Entry-Corporate Name  

Northwestern University Driskill Graduate Training Program in Life Sciences

Host Item Entry  

Dissertations Abstracts International. 85-11B.

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:658191