자료유형  

 학위논문

Control Number  

0017162654

International Standard Book Number  

9798383690901

Dewey Decimal Classification Number  

547

Main Entry-Personal Name  

Sanders, Matthew Alan.

Publication, Distribution, etc. (Imprint  

[S.l.] : The University of North Carolina at Chapel Hill., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

263 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

General Note  

Advisor: Knight, Abigail S.

Dissertation Note  

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2024.

Summary, Etc.  

요약Proteins are extraordinary materials that perform a variety of functions stemming from biology, such as catalysis and analyte binding. These functions originate from protein's unique ability to form precise structures, placing residues in conformations beneficial to their function. These structures can span multiple length scales, from single molecules to assemblies of proteins. However, applications of these materials outside of native biological environments are a challenge, making industrial-scale synthesis and use of proteins often costly. Synthetic macromolecules, on the other hand, have diverse stability and functionality as well as scalable syntheses. However, the study of the hierarchical structures of synthetic macromolecules and their impact on biomimetic functions is comparatively underexplored.Catalysis is a facile method to understand how differences in polymer structure impacts function as rates of reaction can easily be extracted from yield information to glean information about how changing polymer properties impacts the rate of catalysis. Herein we have approached the development of palladium bound triphenylphosphine-containing polymer catalysts and analyzed their reactivity using a model Suzuki-Miyaura cross-coupling reaction modifying polymer properties such as molecular weight and comonomer (Chapter 2). Additionally, we have analyzed the addition of protein-mimetic functional groups, including local structure and electrostatic interactions, as well as incorporation of a bis-phosphine monomer to study the impact of metal-ligand cross-links on these novel polymeric materials (Chapter 3). Further, we endeavored to add strong architectural differences to these materials via the incorporation of covalent cross-linking as well as branching to study the effect of compaction and changes in backbone architecture on catalysis (Appendix A). Lastly, I have endeavored using other biomimetic materials such as peptoids and peptide-polymer amphiphiles to gain information about how the composition of these materials leads to changes in structure and therefore function through multichain assemblies (Appendix B and Appendix C respectively). Together these multifaceted approaches have enhanced our understanding of the structure-function relationships of synthetic macromolecules and have begun bridging the gap between the functionality of synthetic macromolecules and the precise hierarchical structure of biological materials.

Subject Added Entry-Topical Term  

Polymer chemistry.

Subject Added Entry-Topical Term  

Organic chemistry.

Subject Added Entry-Topical Term  

Chemistry.

Subject Added Entry-Topical Term  

Molecular biology.

Subject Added Entry-Topical Term  

Biochemistry.

Index Term-Uncontrolled  

Polymer catalysts

Index Term-Uncontrolled  

Structure-function relationships

Index Term-Uncontrolled  

Suzuki-miyaura cross-couplings

Index Term-Uncontrolled  

Proteins

Index Term-Uncontrolled  

Biological materials

Added Entry-Corporate Name  

The University of North Carolina at Chapel Hill Chemistry

Host Item Entry  

Dissertations Abstracts International. 86-02B.

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:658178