자료유형  

 학위논문

Control Number  

0017164205

International Standard Book Number  

9798384436348

Dewey Decimal Classification Number  

616

Main Entry-Personal Name  

Ma, Liang.

Publication, Distribution, etc. (Imprint  

[S.l.] : Columbia University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

158 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Gelinas, Jennifer N.

Dissertation Note  

Thesis (Ph.D.)--Columbia University, 2024.

Summary, Etc.  

요약Mature neural network functions and their activity correlates are not innate properties of the neonatal brain. Neural network oscillations mediating cognitive processes such as long-term memory require postnatal developmental emergence. Early cortical activity patterns are discontinuous and often externally driven, whereas later in development mature, complex, continuous and internally generated patterns emerge. However, the postnatal time course of this transition of cortical dynamics is poorly characterized. Specific cognitive processes such as memory consolidation and reconsolidation are differentially regulated by precise temporal coupling of hippocampal and cortical oscillations, including sleep spindles, hippocampal sharp wave-ripples, and cortical ripples. Yet the developmental emergence of cortical ripples and its coupling patterns remain unknown, in part due to challenges in recording from distributed brain regions in small immature animals. Furthermore, neurodevelopmental disorders often disrupt activity maturation, but large-scale investigations of pathological network development are lacking. We first conducted in vivo electrophysiology in mice during early development, and identified an evolutionarily conserved developmental trajectory of large-scale cortical dynamics. Next, we developed and validated high-density conformable neural probes (NeuroShanks) for targeting deep brain regions in developing animals. We then used NeuroShanks to investigate ripple-band oscillations in the developing hippocampal-cortical network, and proposed a conceptual model of network maturation. Finally, we extended our methods to uncover early dysregulation and pathological maturation in a pediatric mouse model of genetic epilepsy.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Bioengineering.

Subject Added Entry-Topical Term  

Developmental biology.

Subject Added Entry-Topical Term  

Systematic biology.

Index Term-Uncontrolled  

Computation

Index Term-Uncontrolled  

Development

Index Term-Uncontrolled  

Devices

Index Term-Uncontrolled  

Hippocampus

Index Term-Uncontrolled  

Neocortex

Index Term-Uncontrolled  

Oscillations

Added Entry-Corporate Name  

Columbia University Biomedical Engineering

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:657985