자료유형  

 학위논문

Control Number  

0017162945

International Standard Book Number  

9798384338352

Dewey Decimal Classification Number  

600

Main Entry-Personal Name  

Braunreuther, Margaret.

Publication, Distribution, etc. (Imprint  

[S.l.] : Stanford University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

132 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Fuller, Gerald.

Dissertation Note  

Thesis (Ph.D.)--Stanford University, 2024.

Summary, Etc.  

요약Mucus is a sticky, gel-like fluid secreted by epithelial cells lining the respiratory, gastrointestinal, and reproductive tracts. In the respiratory system, mucus acts as a physical barrier, trapping inhaled pathogens, dust, and pollutants and preventing them from reaching the lung tissue. Mucus clearance, and thus removal of the trapped foreign material, is necessary for healthy immune function.Mucus comprises a viscoelastic network formed primarily by polymeric mucins connected by physical and covalent bonds. The effectiveness of mucus relies on the composition of this network, which regulates its material properties and rheology. Rheology is the study of flow and deformation of complex materials. The rheological properties of mucus, such as viscosity and elasticity, determine its ability to protect the airways and to be transported out of the lungs via coordinated ciliary beating and coughing. In many respiratory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, changes in mucus composition and rheology contribute to impaired mucus clearance and airway obstruction. Thickened and concentrated mucus, coupled with abnormal rheological properties such as increased viscosity, can hinder ciliary function and reduce the effectiveness of the mucociliary transport. As a result, mucus accumulates in the airway, leading to infection, chronic inflammation, and, ultimately, loss of lung function.Characterization of mucus rheology in health and disease is crucial to understanding the underlying mechanisms of disease progression and developing targeted therapeutic strategies to address muco-obstructive disorders. Thus far, rheological studies of mucus have been limited by difficulty of mucus collection, small sample volumes, and changes in properties due to collection and handling procedures. To address these limitations, we have developed an innovative device to measure mucus rheology directly on live human epithelial cell cultures. This method allows us to investigate the intricate relationship between epithelial cell physiology and pathologic mucus secretion.

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Pathogens.

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Glycoproteins.

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Reagents.

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Disease.

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Magnetic fields.

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Biomedical materials.

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Contact angle.

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Human subjects.

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Cell culture.

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Protein expression.

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Cystic fibrosis.

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Homeostasis.

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Gene expression.

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Hyaluronic acid.

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Asthma.

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Viscosity.

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Rheology.

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Genetic engineering.

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Sperm.

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Design.

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Viscoelasticity.

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Hydrogels.

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Bioengineering.

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Bioinformatics.

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Biomedical engineering.

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Cellular biology.

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Electromagnetics.

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Genetics.

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Materials science.

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Mechanics.

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Medicine.

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Physiology.

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Physics.

Added Entry-Corporate Name  

Stanford University.

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:657422