자료유형  

 학위논문

Control Number  

0017160463

International Standard Book Number  

9798382830100

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Xu, Karen.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Pennsylvania., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

220 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Burdick, Jason A.;Mauck, Robert L.

Dissertation Note  

Thesis (Ph.D.)--University of Pennsylvania, 2024.

Summary, Etc.  

요약The cell-ECM crosstalk is critical to maintaining homeostasis and repairing tissue especially in the meniscus, a dense connective tissue in the knee joint that distributes loads. Hydrogels are water-swollen polymer-crosslinked networks that can be used as ECM mimetics to explore this cell-ECM crosstalk. This thesis investigates the central question: how can the extracellular environment support and induce favorable cell-ECM crosstalk towards meniscus repair. By engineering various hydrogel microstructures, this question is explored through two avenues: inducing cell migration for tissue engineering applications and contractility for fibrous tissue development modeling. In the first part, we tune porosity and microinterfaces via granular and bicontinuous hydrogels, respectively, to explore how these cues provide paths that support cell infiltration. In the second part, we mimic the developing meniscus by engineering composite fibrous hydrogels consisting of fragmented electrospun fibers embedded within a continuous phase, whereby crosslinking of the continuous phase enables user-definition of contractility parameters. In total, this thesis contributes to an understanding of hydrogel design and fabrication towards inducing desirable behaviors to provide insights towards meniscus repair.

Subject Added Entry-Topical Term  

Biomedical engineering.

Subject Added Entry-Topical Term  

Chemical engineering.

Subject Added Entry-Topical Term  

Bioengineering.

Index Term-Uncontrolled  

Homeostasis

Index Term-Uncontrolled  

Cell migration

Index Term-Uncontrolled  

Tissue engineering

Index Term-Uncontrolled  

Bicontinuous hydrogels

Added Entry-Corporate Name  

University of Pennsylvania Bioengineering

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:657361