자료유형  

 학위논문

Control Number  

0017163125

International Standard Book Number  

9798384051442

Dewey Decimal Classification Number  

660

Main Entry-Personal Name  

Vadhin, Sandra.

Publication, Distribution, etc. (Imprint  

[S.l.] : Cornell University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

206 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Varner, Jeffrey.

Dissertation Note  

Thesis (Ph.D.)--Cornell University, 2024.

Summary, Etc.  

요약Mathematical modeling is a tool that enables the investigation of phenomena that may be hard to measure or emulate experimentally. Traditional biochemical network modeling approaches are often complex and nonlinear and require the estimation of a large number of unknown parameters. The power-law formalism - or biochemical systems theory (BST) - which is based on generic model descriptions and yields reduced systems of non-linear ordinary differential equations, has become an area of interest since it was proposed in the 1960s by Savageau. The development of accurate lower-order models of biochemical kinetics would potentially streamline the modeling process in many applications. Toward this goal, we developed dynamic power-law models in two overarching topics: coagulopathies and cell-free systems. In this work, our models describe coagulatory and fibrinolytic pathways in pregnant patients, quantifying hypercoagulability at various stages of pregnancy. We then developed models of coagulation in hemophilia patients and were able to predict clotting dynamics. Finally, we developed a model of sequence-specific gene transcription in a cell-free system and successfully captured mRNA dynamics. Taken together, we have developed lower-order models that could be used in clinical, academic, and industrial applications.

Subject Added Entry-Topical Term  

Chemical engineering.

Subject Added Entry-Topical Term  

Biochemistry.

Subject Added Entry-Topical Term  

Bioinformatics.

Index Term-Uncontrolled  

Mathematical modeling

Index Term-Uncontrolled  

Biochemical kinetics

Index Term-Uncontrolled  

Cell-free system

Index Term-Uncontrolled  

Hemophilia patients

Added Entry-Corporate Name  

Cornell University Chemical Engineering

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:657260