자료유형  

 학위논문

Control Number  

0017160908

International Standard Book Number  

9798383219522

Dewey Decimal Classification Number  

576

Main Entry-Personal Name  

Carr, Alex.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Washington., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

133 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

General Note  

Advisor: Baliga, Nitin.

Dissertation Note  

Thesis (Ph.D.)--University of Washington, 2024.

Summary, Etc.  

요약Microbes and the communities they form play critical roles in ecosystem function, from facilitating the biogeochemical cycling of essential nutrients, such as carbon, nitrogen, and sulfur, to acting as the foundation of complex food webs. Microbes also play important roles as eukaryotic symbionts, where they can have profound effects on host fitness. Thus, understanding how microbial community interactions and environmental context shape the functional capabilities of microbiomes is of vital importance if we want to engineer these systems to address challenges in human health and the health of natural ecosystems. Here, I show how systems approaches can be leveraged to overcome the inherent limitations of inferring microbial community interactions directly from correlation structure, which has been the standard approach in the microbiome field. Specifically, I highlight how multi-omic characterization, MCMMs, and synthetic communities (SynComs) can be leveraged to better understand niche competition between nitrate-reducing bacteria and sulfate-reducing bacteria in oxygen-depleted ecosystems, the importance of pathway partitioning in nitrate-reducing communities, and the role of nitrate-reducing communities in nitrous oxide emissions. I also highlight how microbial community-scale metabolic models (MCMMs) can be leveraged to predict Clostridioides difficile (C. difficile) colonization in the human gut microbiome, provide mechanistic insights into the niche of C. difficile across different community contexts, and assess probiotic interventions designed to inhibit C. difficile growth.

Subject Added Entry-Topical Term  

Microbiology.

Subject Added Entry-Topical Term  

Ecology.

Subject Added Entry-Topical Term  

Systematic biology.

Subject Added Entry-Topical Term  

Environmental science.

Subject Added Entry-Topical Term  

Analytical chemistry.

Index Term-Uncontrolled  

Denitrification

Index Term-Uncontrolled  

Human gut microbiome

Index Term-Uncontrolled  

Metabolic modeling

Index Term-Uncontrolled  

Microbial ecology

Index Term-Uncontrolled  

Synthetic communities

Added Entry-Corporate Name  

University of Washington Molecular Engineering and Sciences

Host Item Entry  

Dissertations Abstracts International. 86-01B.

Electronic Location and Access  

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Control Number  

joongbu:657218