Material Type  

 학위논문

 

0017164332

Date and Time of Latest Transaction  

20250211152949

ISBN  

9798346374398

DDC  

610

Author  

Natale, Brianna Nicole.

Title/Author  

Childhood Antecedents of Systemic Inflammation in Adolescence and Adulthood : Contributions of Childhood Family Environment and Socioeconomic Context.

Publish Info  

[S.l.] : University of Pittsburgh., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

104 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-05, Section: A.

General Note  

Advisor: Reed, Rebecca;Hipwell, Alison;Hanson, Jamie;Shaw, Daniel;Marsland, Anna.

학위논문주기  

Thesis (Ph.D.)--University of Pittsburgh, 2024.

Abstracts/Etc  

요약The childhood family environment has been associated with lifelong health trajectories, including cardiometabolic disease morbidity and mortality. Systemic inflammation is one important preclinical marker of cardiometabolic risk, and prior studies have shown that early-life experiences, including family relationship quality and socioeconomic status, are related to circulating levels of inflammatory markers as early as adolescence. The current study utilized data from the Pittsburgh Girls Study to longitudinally investigate links between a childhood family environment latent variable-indicated by harsh punishment, caregiver-partner conflict, and caregiver depression-and inflammation in adolescence (n=429; M age=10.52) and early adulthood (n=1,362; Mage=23.57), while considering additional risk (financial strain) and protective (supportive parenting) factors. Structural equation models found that greater family adversity across ages 5-9 was prospectively associated with higher levels of interleukin (IL)-6 in both adolescence and adulthood, even when adjusting for covariates (e.g., child self-control, pubertal timing). Further adjustment for adolescent waist circumference attenuated the link between the childhood family environment and adult IL-6 to non-significance, and sensitivity analyses revealed that it was a significant mediator of this relationship. When adding financial strain into the models, the childhood family environment was no longer predictive of later inflammation, but there was evidence for associations between childhood financial strain and adult IL-6. Contrary to hypotheses, supportive parenting did not moderate associations between childhood family environment or financial strain and later inflammation. Together, these results suggest that the childhood family environment contributes to long-term systemic inflammation, although not independently of childhood socioeconomic context. The current study offers novel insights into links between childhood stressors and inflammatory profiles across developmental stages and highlights opportunities to further probe biopsychosocial mechanisms underlying these relationships.

Subject Added Entry-Topical Term  

Biomarkers.

Subject Added Entry-Topical Term  

Health behavior.

Subject Added Entry-Topical Term  

Socioeconomic factors.

Subject Added Entry-Topical Term  

Family income.

Subject Added Entry-Topical Term  

Scandals.

Subject Added Entry-Topical Term  

Adverse childhood experiences.

Subject Added Entry-Topical Term  

Teenagers.

Subject Added Entry-Topical Term  

Behavioral psychology.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Home economics.

Subject Added Entry-Topical Term  

Health sciences.

Subject Added Entry-Topical Term  

Sociology.

Added Entry-Corporate Name  

University of Pittsburgh.

Host Item Entry  

Dissertations Abstracts International. 86-05A.

Electronic Location and Access  

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Control Number  

joongbu:657084