자료유형  

 학위논문

Control Number  

0017161969

International Standard Book Number  

9798384018261

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Schafer, Emily A.

Publication, Distribution, etc. (Imprint  

[S.l.] : Northwestern University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

233 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

General Note  

Advisor: Rivnay, Jonathan.

Dissertation Note  

Thesis (Ph.D.)--Northwestern University, 2024.

Summary, Etc.  

요약Bioelectronic devices have made significant contributions to our understanding and treatment of the human body but remain limited by mechanical mismatch and poor signal transduction at the biotic/abiotic interface. Organic mixed ionic-electronic conductors (OMIECs) can build soft, intimate interfaces with biology by translating ionic fluxes from living systems into an electronic current compatible with traditional microelectronics. This class of polymers gives bioelectronics a low electrochemical impedance, enabling sensing of small, otherwise undetectable biological signals. An emerging strategy for biosensor design leverages transmembrane proteins found in cell membranes to drive analyte detection. OMIECs are well-poised to improve these devices because their high biocompatibility and soft mechanics allow them to cushion functional fluid membranes. Combining advances in bioelectronics and synthetic biology therefore generates a new platform that acts both as a tool for mechanistic study of membrane processes and also as a bio-inspired sensor with the same sensing mechanisms as living cells. This thesis addresses challenges in polymer science, device fabrication, lipid and hybrid bilayer formation, and protein engineering to successfully integrate model membranes with organic bioelectronics. In particular, sensor stability and reproducibility are enhanced through tuning of OMIEC properties, lipid composition, and via the class of model membrane. First, I will highlight the shortcomings of current sensor designs based on OMIEC selection and investigate the generalizable sources and mechanism of performance degradation for transistors using polythiophene-based OMIECs. Next, I will demonstrate that supported lipid bilayers on OMIEC electronics can be assembled with blends of phospholipids and synthetic block copolymers to establish membranes with tunable biophysical properties and increased resilience to environmental interferents. Subsequently, I will initiate the first example of droplet bilayers supported by OMIECs to further promote membrane sensor stability and reliability and I will demonstrate integration with microfabricated OMIEC electronic devices and gated membrane proteins. Broadly, the sensors constructed throughout this thesis sustain high integrity membranes with strong electrical sealing and support complex transmembrane proteins sensitive to a range of biological stimuli. This work represents significant progress toward realizing the full potential of organic mixed conductors as biological interfaces and establishing these bio-inspired sensors as an exciting new platform with unique translational promise.

Subject Added Entry-Topical Term  

Biomedical engineering.

Subject Added Entry-Topical Term  

Nanotechnology.

Subject Added Entry-Topical Term  

Biomechanics.

Index Term-Uncontrolled  

Bioelectronics

Index Term-Uncontrolled  

Bioinspired sensor development

Index Term-Uncontrolled  

Conducting polymers

Index Term-Uncontrolled  

Cell membranes

Index Term-Uncontrolled  

Sensors

Added Entry-Corporate Name  

Northwestern University Biomedical Engineering

Host Item Entry  

Dissertations Abstracts International. 86-02B.

Electronic Location and Access  

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Control Number  

joongbu:657025