자료유형  

 학위논문

Control Number  

0017162035

International Standard Book Number  

9798384103073

Dewey Decimal Classification Number  

153

Main Entry-Personal Name  

Anderson, Elizabeth.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, San Diego., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

186 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Ries, Stephanie.

Dissertation Note  

Thesis (Ph.D.)--University of California, San Diego, 2024.

Summary, Etc.  

요약Anomia is a pervasive deficit across individuals with left hemisphere stroke-induced aphasia. Although lexical retrieval is often impaired in individuals with aphasia, the driving forces behind lexical retrieval deficits are not well understood. Lexical activation and selection are key processes enabling us to retrieve words as we speak. Lexical activation occurs through spreading activation from semantic to lexical representations and is facilitated in semantically-related contexts. Lexical selection is the selection of the target word from activated semantically-related alternatives and can be slowed in semantically-related contexts. Lexical retrieval stages can be differently affected depending on the type of semantic context. Taxonomically-related words (e.g., wolf-dog) have been linked with semantic interference. However, thematically-related words (e.g., dog-leash) have been linked with facilitation. Across four studies, this dissertation analyzes the spatiotemporal dynamics of lexical retrieval to further characterize the neural regions and processes underlying lexical retrieval and how these may be differentially impacted depending on the type of semantic context. The results show that taxonomically-related contexts cause semantic interference and are associated with a larger negative-going component in the 300-500 ms time window restricted to a left frontal recording site in both young and older control participants. This component is absent in individuals with aphasia regardless of their lesion site. However, individuals with brain lesions including the left posterior temporal cortex showed impairments in lexical activation, preceding lexical selection, and inner speech monitoring as indicated by an impaired medial frontal error-related electrophysiological component. Intracranial data revealed that medial and superior frontal regions typically associated with conflict resolution are also engaged during spreading activation during picture naming. The results of these studies provide a key step towards understanding the brain dynamics of lexical retrieval in stroke-induced aphasia, including how different lexical retrieval deficits interact with semantic contexts, and providing a knowledge basis for the future development of clinical tools for lexical retrieval.

Subject Added Entry-Topical Term  

Cognitive psychology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Psychobiology.

Subject Added Entry-Topical Term  

Physiological psychology.

Index Term-Uncontrolled  

Lexical retrieval

Index Term-Uncontrolled  

Semantic context

Index Term-Uncontrolled  

Aphasia

Index Term-Uncontrolled  

Anomia

Index Term-Uncontrolled  

Electroencephalography

Added Entry-Corporate Name  

University of California, San Diego Language and Communicative Disorders (Joint Doctoral with SDSU)

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:656792