자료유형  

 학위논문

Control Number  

0017164536

International Standard Book Number  

9798384045632

Dewey Decimal Classification Number  

150

Main Entry-Personal Name  

Cleary, Jennifer.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Michigan., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

70 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-04, Section: B.

General Note  

Advisor: Sen, Srijan.

Dissertation Note  

Thesis (Ph.D.)--University of Michigan, 2024.

Summary, Etc.  

요약The overarching aim of this dissertation is to investigate independent and joint contributions of genetic factors and social environment in risk of psychopathology under a variety of stressful environments. In Study 1, we capitalize on recent advances in genomic technology and the measurement of social and environmental characteristics in two distinct populations to investigate gene x environment interactions in depressive symptoms. Here, we address the dissertation's Specific Aim 1: to test gene x environment interactions in predicting psychopathology under stress using polygenic risk scores for major depressive disorder (MDD). In Study 2, we characterize changes in depressive symptoms among frontline healthcare workers during the COVID-19 pandemic, and the associated changes in their work environments. Using causal mediation analysis, we address the dissertation's Specific Aim 2: to investigate trajectories of depressive symptoms during a global stressor, and identify potential sources of support for future intervention. In both studies, we apply advanced quantitative methods to large, longitudinal datasets to extend the literature on the potential causes of depressive symptoms. Taken together, these studies consider variability at the levels of genetics, individual and global psychosocial stressors, and interpersonal and institutional social support as they relate to the development of depressive symptoms. 

Subject Added Entry-Topical Term  

Psychology.

Subject Added Entry-Topical Term  

Clinical psychology.

Subject Added Entry-Topical Term  

Mental health.

Subject Added Entry-Topical Term  

Social psychology.

Subject Added Entry-Topical Term  

Genetics.

Index Term-Uncontrolled  

Depression risk

Index Term-Uncontrolled  

Social support

Index Term-Uncontrolled  

Genomic technology

Index Term-Uncontrolled  

Social environment

Index Term-Uncontrolled  

COVID-19 pandemic

Added Entry-Corporate Name  

University of Michigan Psychology

Host Item Entry  

Dissertations Abstracts International. 86-04B.

Electronic Location and Access  

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Control Number  

joongbu:656735