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Development and Translation of Novel Hyperpolarized C-13 MRI Technologies for Prostate Cancer Clinical Research.
Development and Translation of Novel Hyperpolarized C-13 MRI Technologies for Prostate Cancer Clinical Research.
상세정보
- 자료유형
- 학위논문
- Control Number
- 0017164623
- International Standard Book Number
- 9798346875031
- Dewey Decimal Classification Number
- 610
- Main Entry-Personal Name
- Gebrezgiabhier, Daniel.
- Publication, Distribution, etc. (Imprint
- [S.l.] : University of California, San Francisco., 2024
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- Physical Description
- 192 p.
- General Note
- Source: Dissertations Abstracts International, Volume: 86-06, Section: B.
- General Note
- Advisor: Vigneron, Dan.
- Dissertation Note
- Thesis (Ph.D.)--University of California, San Francisco, 2024.
- Summary, Etc.
- 요약Prostate cancer is one of the most common cancers in men and second leading cause of death cancer in the United States of America. Current clinical imaging modalities provide limited information on prostate cancer aggressiveness and response to therapy required for optimal patient management. To reduce the mortality rates, early detection and diagnosis of prostate cancer is crucial. Thus, there is a clinical need for improved noninvasive accurate histopathologic diagnosis and grading of prostate cancer. Currently, transrectal ultrasonography (TRUS)-guided biopsy is the standard approach for histopathologic diagnosis and grading of prostate cancer. However, TRUS is limited for directly visualizing and targeting prostate lesions and therefore the fusion of magnetic resonance (MR) images with US was developed to overcome many of these limitations. The development of endorectal (ER) coils has further improved prostate tumor visualization on MR images as the endorectal coil used in an MRI-guided prostate biopsy helps provide more detailed images from the prostate and surrounding structures. However, conventional anatomic and diffusion MR images do not provide metabolic information on prostate cancer aggressiveness and extent. Recent studies with the emerging hyperpolarized (HP) carbon-13 (13C) MR imaging technique have shown that hyperpolarized (HP) 13C-pyruvate MRI in a rapid 1-minute addition to conventional proton MRI exams can detect metabolic reprogramming in prostate cancer improving the detection of aggressive cancers and for monitoring response to therapy. Dual-agent ([1- 13C]-pyruvate, [1- 13C, 15N2]-urea) hyperpolarized 13C MRI can also be used to simultaneously assess tumor metabolism and tissue perfusion in patients with localized prostate cancer; Thus, this project was designed to develop specialized hardware and software to enable multiparametric MR incorporating hyperpolarized (HP) 13C MR molecular imaging for improved characterization and MR- US fusion biopsy guidance. In this dissertation project, new methods and detector hardware to acquire and display 13C-pyruvate to 13C-lactate conversion rate constants (kPL) images were developed and applied for guiding MR-US fusion biopsies in prostate cancer patients for the first time.
- Subject Added Entry-Topical Term
- Bioengineering.
- Subject Added Entry-Topical Term
- Biomedical engineering.
- Subject Added Entry-Topical Term
- Engineering.
- Subject Added Entry-Topical Term
- Oncology.
- Index Term-Uncontrolled
- Active surveillance metabolic imaging
- Index Term-Uncontrolled
- Magnetic resonance images
- Index Term-Uncontrolled
- Prostate cancer
- Index Term-Uncontrolled
- Death cancer
- Index Term-Uncontrolled
- Biopsy guidance
- Added Entry-Corporate Name
- University of California, San Francisco Bioengineering
- Host Item Entry
- Dissertations Abstracts International. 86-06B.
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:656667
MARC
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■020 ▼a9798346875031
■035 ▼a(MiAaPQ)AAI31633170
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a610
■1001 ▼aGebrezgiabhier, Daniel.▼0(orcid)0000-0002-8118-3931
■24510▼aDevelopment and Translation of Novel Hyperpolarized C-13 MRI Technologies for Prostate Cancer Clinical Research.
■260 ▼a[S.l.]▼bUniversity of California, San Francisco. ▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a192 p.
■500 ▼aSource: Dissertations Abstracts International, Volume: 86-06, Section: B.
■500 ▼aAdvisor: Vigneron, Dan.
■5021 ▼aThesis (Ph.D.)--University of California, San Francisco, 2024.
■520 ▼aProstate cancer is one of the most common cancers in men and second leading cause of death cancer in the United States of America. Current clinical imaging modalities provide limited information on prostate cancer aggressiveness and response to therapy required for optimal patient management. To reduce the mortality rates, early detection and diagnosis of prostate cancer is crucial. Thus, there is a clinical need for improved noninvasive accurate histopathologic diagnosis and grading of prostate cancer. Currently, transrectal ultrasonography (TRUS)-guided biopsy is the standard approach for histopathologic diagnosis and grading of prostate cancer. However, TRUS is limited for directly visualizing and targeting prostate lesions and therefore the fusion of magnetic resonance (MR) images with US was developed to overcome many of these limitations. The development of endorectal (ER) coils has further improved prostate tumor visualization on MR images as the endorectal coil used in an MRI-guided prostate biopsy helps provide more detailed images from the prostate and surrounding structures. However, conventional anatomic and diffusion MR images do not provide metabolic information on prostate cancer aggressiveness and extent. Recent studies with the emerging hyperpolarized (HP) carbon-13 (13C) MR imaging technique have shown that hyperpolarized (HP) 13C-pyruvate MRI in a rapid 1-minute addition to conventional proton MRI exams can detect metabolic reprogramming in prostate cancer improving the detection of aggressive cancers and for monitoring response to therapy. Dual-agent ([1- 13C]-pyruvate, [1- 13C, 15N2]-urea) hyperpolarized 13C MRI can also be used to simultaneously assess tumor metabolism and tissue perfusion in patients with localized prostate cancer; Thus, this project was designed to develop specialized hardware and software to enable multiparametric MR incorporating hyperpolarized (HP) 13C MR molecular imaging for improved characterization and MR- US fusion biopsy guidance. In this dissertation project, new methods and detector hardware to acquire and display 13C-pyruvate to 13C-lactate conversion rate constants (kPL) images were developed and applied for guiding MR-US fusion biopsies in prostate cancer patients for the first time.
■590 ▼aSchool code: 0034.
■650 4▼aBioengineering.
■650 4▼aBiomedical engineering.
■650 4▼aEngineering.
■650 4▼aOncology.
■653 ▼aActive surveillance metabolic imaging
■653 ▼aMagnetic resonance images
■653 ▼aProstate cancer
■653 ▼aDeath cancer
■653 ▼aBiopsy guidance
■690 ▼a0202
■690 ▼a0541
■690 ▼a0537
■690 ▼a0992
■71020▼aUniversity of California, San Francisco▼bBioengineering.
■7730 ▼tDissertations Abstracts International▼g86-06B.
■790 ▼a0034
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17164623▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
