자료유형  

 학위논문

Control Number  

0017164710

International Standard Book Number  

9798346877608

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Bond, Elizabeth A.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, San Francisco., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

72 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-06, Section: B.

General Note  

Advisor: Booth, David.

Dissertation Note  

Thesis (Ph.D.)--University of California, San Francisco, 2024.

Summary, Etc.  

요약Pathogenic bacteria rely on a myriad of survival mechanisms to successfully establish their infection niche. This includes methods of immune evasion, nutrient switching, and environmental adaptation. In Listeria monocytogenes, the causative agent of listeriosis, environmental adaptation is regulated by a macromolecular machine known as the stressosome. The stressosome is a megadalton cytosolic protein complex that geometrically takes on a pseudo-icosahedron. Comprised primarily of multiple copies of three proteins RsbR, RsbS and a kinase RsbT, the stressosome is responsible for sensing changes in pH, salt, ethanol, and light. Stressosome activation and assembly are tightly linked to phosphorylation state; however, we have limited information about how phosphorylation impacts the stressosome structurally. Here in Chapter 1, I will provide a brief introduction into my PhD project, in Chapter 2, I will present my findings on the role of phosphorylation in stressosome assembly, and finally in Chapter 3, I will share preliminary work on stressosome assembly related to a phosphatase, RsbX.

Subject Added Entry-Topical Term  

Biochemistry.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Molecular biology.

Index Term-Uncontrolled  

Listeria monocytogenes

Index Term-Uncontrolled  

Phosphorylation

Index Term-Uncontrolled  

Stress response

Index Term-Uncontrolled  

Stressosome

Index Term-Uncontrolled  

Structural biology

Added Entry-Corporate Name  

University of California, San Francisco Biochemistry and Molecular Biology

Host Item Entry  

Dissertations Abstracts International. 86-06B.

Electronic Location and Access  

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Control Number  

joongbu:656605