자료유형  

 학위논문

Control Number  

0017164747

International Standard Book Number  

9798346851134

Dewey Decimal Classification Number  

004

Main Entry-Personal Name  

Marrett, Karl.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Los Angeles., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

123 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-06, Section: B.

General Note  

Advisor: Cong, Jason.

Dissertation Note  

Thesis (Ph.D.)--University of California, Los Angeles, 2024.

Summary, Etc.  

요약Neuronal reconstruction-a process that transforms image volumes into 3D geometries and skeletons of cells-bottlenecks the study of brain function, connectomics and pathology. Scientists need exact and complete segmentations to study subtle topological differences. Existing methods are disk-bound, dense-access, coupled, single-threaded, algorithmically unscalable and require manual cropping of small windows and proofreading of skeletons due to low topological accuracy. Designing a data-intensive parallel solution suited to a neurons' shape, topology and far-ranging connectivity is particularly challenging due to I/O and load-balance, yet by abstracting vision tasks such as segmentation and skeletonization into strategically ordered specializations of search, we progressively lower memory by 4 orders of magnitude. This enables 1 mouse brain to be fully processed in-memory on a single server, at 67x the scale with 870x less memory while having 78% higher automated yield than APP2, the standard of performant reconstruction.

Subject Added Entry-Topical Term  

Computer science.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Bioengineering.

Index Term-Uncontrolled  

Neuronal reconstruction

Index Term-Uncontrolled  

Topological accuracy

Index Term-Uncontrolled  

Proofreading

Index Term-Uncontrolled  

Skeletonization

Added Entry-Corporate Name  

University of California, Los Angeles Computer Science 0201

Host Item Entry  

Dissertations Abstracts International. 86-06B.

Electronic Location and Access  

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Control Number  

joongbu:656593