자료유형  

 학위논문

Control Number  

0017164724

International Standard Book Number  

9798346758570

Dewey Decimal Classification Number  

610

Main Entry-Personal Name  

Li, Xiyao.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Los Angeles., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

119 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-06, Section: B.

General Note  

Advisor: Li, Song.

Dissertation Note  

Thesis (Ph.D.)--University of California, Los Angeles, 2024.

Summary, Etc.  

요약Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide. For most HNSCC patients with locally advanced disease, platinum-based drugs, especially cisplatin, remain the gold standard to reduce the risk of recurrence and improve survival rate. Drug resistance, however, is the main issue obstructing the optimum cisplatin therapeutic efficiency. In this dissertation research, two auxiliary systems were designed to overcome the cisplatin resistance in HNSCC. The first system loaded a small molecule drug with high therapeutic efficacy into polymer microparticles. Upon the intratumoral injection through microneedle, a local and sustained release was achieved, leading to suppressed proliferation, inhibited migration, and promoted apoptosis of cancer cells. The second system involves the design of a novel enzyme delivery system to target tumor microenvironment, which not only reduces cancer cell viability, migration, and invasion, but also activates immune response. The strategies described in this dissertation research can be extended to other small molecule drugs or therapeutic proteins for cancer therapies beyond cisplatin-resistant HNSCC, providing a platform for more effective cancer therapy.

Subject Added Entry-Topical Term  

Bioengineering.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Oncology.

Index Term-Uncontrolled  

Cancer therapy

Index Term-Uncontrolled  

Head and neck squamous cell carcinoma

Index Term-Uncontrolled  

Polymer microparticles

Added Entry-Corporate Name  

University of California, Los Angeles Bioengineering 0288

Host Item Entry  

Dissertations Abstracts International. 86-06B.

Electronic Location and Access  

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Control Number  

joongbu:656412