자료유형  

 학위논문

Control Number  

0017164080

International Standard Book Number  

9798384054290

Dewey Decimal Classification Number  

574.191

Main Entry-Personal Name  

Loiseau, Gilbert Jamilla.

Publication, Distribution, etc. (Imprint  

[S.l.] : The University of Wisconsin - Madison., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

183 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Senes, Alessandro.

Dissertation Note  

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2024.

Summary, Etc.  

요약Membrane protein folding occurs as a result of an equilibrium of biophysical forces. Polar and charged interactions can drive folding within the hydrophobic environment of the membrane. The stabilizing effects of sidechain packing on membrane protein folding were deduced in a variety of foundational bacteriorhodopsin studies, and sidechain packing as a driving force has been demonstrated through modern protein re-design of phospholamban. However, the extent at which packing can act as a driving force in general in membrane protein systems is not well understood. We investigate the impact of sidechain packing on membrane protein association by using computational design. By sampling dimer conformations from the PDB, we designed hundreds of sequences that self-associate. Structural characterization through mutations on these proteins suggests that packing is a weak driving force in a variety of membrane protein systems.

Subject Added Entry-Topical Term  

Biophysics.

Subject Added Entry-Topical Term  

Computational physics.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Biochemistry.

Index Term-Uncontrolled  

Computational design

Index Term-Uncontrolled  

Membrane protein

Index Term-Uncontrolled  

Sidechain packing

Index Term-Uncontrolled  

Van der Waals packing

Index Term-Uncontrolled  

Phospholamban

Added Entry-Corporate Name  

The University of Wisconsin - Madison Biochemistry-ALS

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:656329