자료유형  

 학위논문

Control Number  

0017161009

International Standard Book Number  

9798382295978

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Webster, Jace.

Publication, Distribution, etc. (Imprint  

[S.l.] : Washington University in St. Louis., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

115 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

General Note  

Advisor: Maher, Christopher.

Dissertation Note  

Thesis (Ph.D.)--Washington University in St. Louis, 2024.

Summary, Etc.  

요약Prostate cancer (PCa) accounts for 29% of all expected cancer diagnoses in men in 2024, but patients presenting with different disease stages can have significantly different outcomes. Patients with indolent PCa may experience little to no impact on their quality of life and have a 5-year survival as high as 98%, but progression to aggressive disease causes 5-year survival to plummet to 30%. Patients with the most lethal form of the disease, metastatic castration-resistant PCa (mCRPC), have a median survival of only 5.5 months if they become resistant to treatment. Due to this clinical heterogeneity, it is critical to quickly and accurately stratify patients to match them with the appropriate treatment plans. To address this need, this thesis focuses on the development of novel tools that may be applied to diagnostic and prognostic biomarker detection in PCa by 1) creating a pipeline to aid in analysis of liquid biopsies, 2) developing a tool for discovering fusion-derived circular RNAs as potential biomarkers and 3) identifying an epigenetic signature for stratification of localized PCa.

Subject Added Entry-Topical Term  

Bioinformatics.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Oncology.

Subject Added Entry-Topical Term  

Genetics.

Index Term-Uncontrolled  

Biomarker

Index Term-Uncontrolled  

Genomics

Index Term-Uncontrolled  

Liquid biopsies

Index Term-Uncontrolled  

Prostate cancer

Added Entry-Corporate Name  

Washington University in St. Louis Biology & Biomedical Sciences (Human & Statistical Genetics)

Host Item Entry  

Dissertations Abstracts International. 85-10B.

Electronic Location and Access  

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Control Number  

joongbu:656156