JOONGBU UNIVERSITY LIBRARY

Contents Info

Progress Toward the Total Synthesis of Pilosanone C.

General Note: Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

Abstracts/Etc: 요약Clerodane diterpenes are a large family of secondary metabolites found in hundreds of plant species and prokaryotes. Since 1990, many examples of the clerodane family have been isolated and characterized. Representative compounds are known to possess significant biological properties, notably, insect antifeedant, opioid receptor agonist and hallucinogenic. The basic structure of clerodanes are bicyclic diterpenoids which primarily exist as a 6-6 ring system. The pilosanones are a subset of the clerodane family which contain a unique 6-7 bicylo[5.4.0]undecane ring system. Pilosanone C 1 has a characteristic oxabicyclo[3.2.1]octene core with four contiguous stereocenters, one of which is a quaternary carbon. There are no reports of synthesis studies in pursuit of this target. Much progress has been made in our laboratories to synthesize the natural product including a route to attempt a late-stage metal catalyzed stereoselective [4+3] cyclization, an early stage intramolecular oxidopyrylium [5+2] cycloaddition, and a chiral pool strategy beginning with (R)-(−)-Carvone.

Material
Reg No.	Call No.	Location	Status	Lend Info
TQ0032252	T	원문자료	열람가능/출력가능	열람가능/출력가능 마이폴더 부재도서신고

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