자료유형  

 학위논문

Control Number  

0017163348

International Standard Book Number  

9798383704899

Dewey Decimal Classification Number  

547

Main Entry-Personal Name  

Wagner-Carlberg, Noah.

Publication, Distribution, etc. (Imprint  

[S.l.] : Columbia University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

289 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

General Note  

Advisor: Rovis, Tomislav.

Dissertation Note  

Thesis (Ph.D.)--Columbia University, 2024.

Summary, Etc.  

요약Due to their large-scale production by the oil refinement industry, alkenes are some of the most ubiquitous starting materials in organic chemistry. The synthesis of many building block chemicals can be traced back to an alkene functionalization reaction. One alkene functionalization that remains underexplored is the introduction of amides. Amide formation is incredibly important, as it is the most common functional group found in bioactive molecules, and amide bond formation is the most common reaction in medicinal chemistry. My thesis will discuss several new methodologies for converting simple alkene starting materials into value-added amide products. First, I will talk about an anti-Markovnikov alkene hydroamidation procedure. Next, I will talk about leveraging chain walking to enable remote hydroamidation of internal alkenes. Finally, I will talk about alkene difunctionalization via nucleometalation to yield heterocyclic products with amides appended. In addition to reaction development, much of the talk will focus on elucidating and studying the mechanisms of each of these transformations.

Subject Added Entry-Topical Term  

Organic chemistry.

Subject Added Entry-Topical Term  

Chemistry.

Subject Added Entry-Topical Term  

Analytical chemistry.

Index Term-Uncontrolled  

Alkene

Index Term-Uncontrolled  

Amidation

Index Term-Uncontrolled  

Catalysis

Index Term-Uncontrolled  

Rhodium

Index Term-Uncontrolled  

Synthesis

Added Entry-Corporate Name  

Columbia University Chemistry

Host Item Entry  

Dissertations Abstracts International. 86-02B.

Electronic Location and Access  

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Control Number  

joongbu:656057