자료유형  

 학위논문

Control Number  

0017165047

International Standard Book Number  

9798346565802

Dewey Decimal Classification Number  

616

Main Entry-Personal Name  

Logan-Garbisch, Theresa.

Publication, Distribution, etc. (Imprint  

[S.l.] : Stanford University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

121 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-05, Section: B.

General Note  

Advisor: Goodman, Miriam.

Dissertation Note  

Thesis (Ph.D.)--Stanford University, 2024.

Summary, Etc.  

요약Throughout history, humans have relied on plants for medication, flavoring, and food, and these plants have also coexisted in ecological communities with other plants, fungi, and animals for millions of years, evolving mechanisms of chemical communication. They release wide arrays of compounds into the environment, affecting animal and microbe behavior. Nematodes, like Caenorhabditis elegans, living in such communities must distinguish harmful from beneficial molecules. In this thesis, I present first a new platform we used to determine the chemotaxis valence of single molecules in C. elegans. In a screen of 90 plant molecules, 37 affected wild-type animals. Analysis of mutants defective in chemosensory ion channels reveals that most compounds relied on multiple ion channels, and chemotaxis valence is more likely to reflect an integration of neural signals than a labeled line. Using this platform, I further examined whether the biosynthetic precursors of natural products could also elicit responses, possibly as a co-evolutionary remnant. Many organisms, including plants and fungi, synthesize the strong attractants isoamyl alcohol and 2-methyl-1-butanol, and, when well-fed, wild-type and mutant nematodes exhibited weak or absent responses to precursor molecules, suggesting that they could be detected but were not particularly motivating. Following prolonged starvation, chemotactic responses were altered in two primary ways: responsiveness decreased to both strong attractants, and a new sensitivity to a precursor compound reliant on OSM-9 TRP channel signaling was revealed. These data also provided additional support for neural signal integration of chemosensory cues. Future studies will be needed to understand how starvation induces these changes in chemosensory behavior and signal integration. Understanding these dynamics sheds light on complex community interactions.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Worms.

Subject Added Entry-Topical Term  

Success.

Subject Added Entry-Topical Term  

Butterflies & moths.

Subject Added Entry-Topical Term  

Communication.

Subject Added Entry-Topical Term  

Dissection.

Subject Added Entry-Topical Term  

Funding.

Subject Added Entry-Topical Term  

Solvents.

Subject Added Entry-Topical Term  

Entomology.

Added Entry-Corporate Name  

Stanford University.

Host Item Entry  

Dissertations Abstracts International. 86-05B.

Electronic Location and Access  

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Control Number  

joongbu:655765