자료유형  

 학위논문

Control Number  

0017163522

International Standard Book Number  

9798384053897

Dewey Decimal Classification Number  

616

Main Entry-Personal Name  

Huang, Xu .

Publication, Distribution, etc. (Imprint  

[S.l.] : Cornell University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

72 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Goldberg, Jesse.

Dissertation Note  

Thesis (Ph.D.)--Cornell University, 2024.

Summary, Etc.  

요약Accurate execution of goal-directed behaviors requires rapid adjustments to ongoing movements to correct for potential errors. Well-coordinated chewing, swallowing and vocalizing rely on the tongue to make such online corrections based on real-time sensory information. However, the neural circuits necessary for this process are largely unknown. Does the tongue employ the same neural circuits used by other effectors to make online corrections? Does the tongue engage different brain regions for different types of online corrections?The cerebellum has been implicated in both rapid online corrections and lingual control. Here, I used both acute and permanent perturbations of the cerebellum to study its involvement in online corrections of tongue movements. I leveraged the advantages of the head-fixed mouse preparation and high spatiotemporal resolution tongue imaging to study touch- and miss-guided online corrections in two different lick paradigms.In chapter 2, I tested the hypothesis that FN is necessary to touch-guided online corrections in a left/right double-step paradigm. Mice preserved the ability to re-aim subsequent licks based on touch information from previous licks after bilateral FN lesion, which argued against the hypothesis.In chapter 3, I tested the involvements of FN and ALM in miss-guided online corrections with a retraction double-step paradigm. Miss-guided online corrections were impaired with Crus bilaterally photoactivated, but remained intact after bilateral FN lesions. The distinct effects yielded from acute photomanipulation and permanent lesion inspired me to revisit the anterolateral motor cortex (ALM), an area established in previous work to be important to miss-guided corrections based on its photoinactivation-induced impairments and neural activity (Bollu & Ito et al., 2021). Surprisingly, my results showed that CSMs and spout contact remained intact after bilateral ALM lesions. Together, these findings suggest that intact FN or ALM is not necessary for miss-guided corrections. Although my lesion results ruled out FN and ALM for a minimal neural circuit underlying miss-guided CSMs and spout contact, when taken together with findings from acute photomanipulations, they suggest an important facilitative role for these areas. 

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Behavioral sciences.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Medical imaging.

Subject Added Entry-Topical Term  

Behavioral psychology.

Index Term-Uncontrolled  

Cerebellum

Index Term-Uncontrolled  

Corrective submovements

Index Term-Uncontrolled  

Lesion

Index Term-Uncontrolled  

Online corrections

Index Term-Uncontrolled  

Photomanipulation

Index Term-Uncontrolled  

Tongue imaging

Added Entry-Corporate Name  

Cornell University Neurobiology and Behavior

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

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Control Number  

joongbu:655531