Material Type  

 학위논문

 

0017165010

Date and Time of Latest Transaction  

20250211153113

ISBN  

9798384462064

DDC  

150

Author  

Li, Jin.

Title/Author  

Visual Word Form Area, a Window Into the Functional Specificity, Origins, and Development of Category-Selective Regions.

Publish Info  

[S.l.] : The Ohio State University., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

290 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-04, Section: B.

General Note  

Advisor: Saygin, Zeynep M.

학위논문주기  

Thesis (Ph.D.)--The Ohio State University, 2024.

Abstracts/Etc  

요약While you are reading this sentence, have you ever thought about what is happening in your brain that allows you to perceive these abstract symbols as words and extract meaning from them? Have you ever thought about how learning to read, a uniquely human skill, plastically shapes your brain's functional organization? Strikingly, researchers found that within the left ventral temporal cortex-the high-level visual cortex that houses regions specialized for processing various abstract visual stimuli like faces and objects-there is also a small region that responds to written words and letters (thus called the visual word form area, VWFA) across many writing systems and languages. Critically, the VWFA serves as a unique example for us to investigate how the human brain develops its mosaic-like functional organization. In this dissertation, I aimed to: 1) comprehensively characterize the functional nature of the VWFA to settle any lingering debates, 2) explore factors that contribute to the emergence of the canonical VWFA, and 3) investigate the developmental trajectory of the VWFA and explore neural factors that might contribute to the developmental changes of the VWFA. These aims were accomplished through a series of studies in four corresponding chapters. In Chapter 2, I examined the VWFA's response to a wide range of visual and nonvisual stimuli to demonstrate its word-selective nature as well as to provide a more complete functional response profile of this region. In Chapter 3, by investigating functional connectivity in neonates, I asked to what extent the cortical tissue that will later become the VWFA already showed adult-like preferential connectivity with the putative frontotemporal language regions. In Chapter 4, I presented unique lesion data to explore the neural consequence of a missing typical language cortex-therefore disrupting the typical VWFA-language connection at birth-on the emergence of a canonical VWFA. In Chapter 5, I utilized longitudinal data in young children to characterize developmental changes in the VWFA's word selectivity, as well as its relationship, if any, with changes in other category selectivity; and with a longitudinal prediction approach, I explored how changes in different neural factors, including structural and functional connectivity and changes in responses to other nonword stimuli, might collectively contribute to changes in word selectivity over time. Overall, this dissertation provides a comprehensive investigation into the functional properties of the VWFA, shedding light on the factors underlying the emergence and development of word selectivity. It offers valuable insights into the specific mechanisms by which various neural factors might shape brain function.  

Subject Added Entry-Topical Term  

Psychology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Cognitive psychology.

Subject Added Entry-Topical Term  

Biomedical engineering.

Subject Added Entry-Topical Term  

Medical imaging.

Index Term-Uncontrolled  

High-level vision

Index Term-Uncontrolled  

Orthographic processing

Index Term-Uncontrolled  

Visual word

Index Term-Uncontrolled  

Category-selective regions

Index Term-Uncontrolled  

MRI

Index Term-Uncontrolled  

Neuroimaging

Added Entry-Corporate Name  

The Ohio State University Psychology

Host Item Entry  

Dissertations Abstracts International. 86-04B.

Electronic Location and Access  

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Control Number  

joongbu:655488