자료유형  

 학위논문

Control Number  

0017160189

International Standard Book Number  

9798383563427

Dewey Decimal Classification Number  

547

Main Entry-Personal Name  

Greenwood, Nathaniel Scott.

Publication, Distribution, etc. (Imprint  

[S.l.] : Yale University., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

820 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

General Note  

Advisor: Ellman, Jonathan A.

Dissertation Note  

Thesis (Ph.D.)--Yale University, 2024.

Summary, Etc.  

요약Functionalization of imine C−H bonds allows for rapid and modular synthesis of nitrogen heterocycles which are present in nearly two-thirds of U.S. FDA approved drugs. The first chapter describes work on the synthesis of a class of nitrogen heterocycles by a new type of reaction, imidoyl C−H carbamylation. Unconventional chiral sulfur(VI) compounds, such as sulfoximines are also increasingly relevant to drug and agrochemical discovery. The second chapter details a catalytic enantioselective sulfur-alkylation of N-acylsulfenamides to access enantioenriched sulfilimine intermediates en route to sulfoximines. The third and fourth chapters demonstrate further methods to access sulfilimines by way of sulfur-arylation with commercially abundant boronic acid and aryl iodide inputs, respectively. Finally, the fifth chapter describes orthogonal methods to access N-acylsulfenamide starting inputs from abundant and diverse commercial materials through a sulfur-functionalization and elimination strategy.

Subject Added Entry-Topical Term  

Organic chemistry.

Index Term-Uncontrolled  

Catalysis

Index Term-Uncontrolled  

Copper

Index Term-Uncontrolled  

Enantioselective

Index Term-Uncontrolled  

Heterocycles

Index Term-Uncontrolled  

Rhodium

Index Term-Uncontrolled  

Sulfur

Added Entry-Corporate Name  

Yale University Chemistry

Host Item Entry  

Dissertations Abstracts International. 86-01B.

Electronic Location and Access  

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Control Number  

joongbu:655353