자료유형  

 학위논문

Control Number  

0017162438

International Standard Book Number  

9798382837307

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Agdanowski, Matthew Paul.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Los Angeles., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

228 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Rodriguez, Jose Alfonso.

Dissertation Note  

Thesis (Ph.D.)--University of California, Los Angeles, 2024.

Summary, Etc.  

요약In the last few decades there has been tremendous technological and computational advances in the field of cryo-electron microscopy which has led to a phenomena referred to as "The Resolution Revolution," in which the number of high resolution structures solved via this technique has exploded. Despite these advances, there still remains a size limitation for your target of interest, below which high resolution microscopy remains challenging. Adding to this, a vast majority of the biologically relevant proteins and nucleic acids inside of cells lie below this size limit. Parallel advances in protein design may provide an avenue for progress on this challenging problem. By designing large protein assemblies, we are able to artificially increase the size of a given target, making it amenable to cryo-EM studies. This thesis describes recent advances in the field as well as efforts to generate imaging scaffolds for both small cancer-related protein targets, and RNA molecules. The knowledge gained through these endeavors will better guide future design efforts.

Subject Added Entry-Topical Term  

Biochemistry.

Subject Added Entry-Topical Term  

Oncology.

Subject Added Entry-Topical Term  

Genetics.

Subject Added Entry-Topical Term  

Nanoscience.

Index Term-Uncontrolled  

Cryo-EM

Index Term-Uncontrolled  

Crystallography

Index Term-Uncontrolled  

Protein design

Index Term-Uncontrolled  

RNA

Index Term-Uncontrolled  

Scaffolds

Added Entry-Corporate Name  

University of California, Los Angeles Biochemistry Molecular and Structural Biology 0090

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:654782