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Protein Nanomaterials as Tools for Cryo-EM Structural Analysis.
Protein Nanomaterials as Tools for Cryo-EM Structural Analysis.
상세정보
- 자료유형
- 학위논문
- Control Number
- 0017162438
- International Standard Book Number
- 9798382837307
- Dewey Decimal Classification Number
- 574
- Main Entry-Personal Name
- Agdanowski, Matthew Paul.
- Publication, Distribution, etc. (Imprint
- [S.l.] : University of California, Los Angeles., 2024
- Publication, Distribution, etc. (Imprint
- Ann Arbor : ProQuest Dissertations & Theses, 2024
- Physical Description
- 228 p.
- General Note
- Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
- General Note
- Advisor: Rodriguez, Jose Alfonso.
- Dissertation Note
- Thesis (Ph.D.)--University of California, Los Angeles, 2024.
- Summary, Etc.
- 요약In the last few decades there has been tremendous technological and computational advances in the field of cryo-electron microscopy which has led to a phenomena referred to as "The Resolution Revolution," in which the number of high resolution structures solved via this technique has exploded. Despite these advances, there still remains a size limitation for your target of interest, below which high resolution microscopy remains challenging. Adding to this, a vast majority of the biologically relevant proteins and nucleic acids inside of cells lie below this size limit. Parallel advances in protein design may provide an avenue for progress on this challenging problem. By designing large protein assemblies, we are able to artificially increase the size of a given target, making it amenable to cryo-EM studies. This thesis describes recent advances in the field as well as efforts to generate imaging scaffolds for both small cancer-related protein targets, and RNA molecules. The knowledge gained through these endeavors will better guide future design efforts.
- Subject Added Entry-Topical Term
- Biochemistry.
- Subject Added Entry-Topical Term
- Oncology.
- Subject Added Entry-Topical Term
- Genetics.
- Subject Added Entry-Topical Term
- Nanoscience.
- Index Term-Uncontrolled
- Cryo-EM
- Index Term-Uncontrolled
- Crystallography
- Index Term-Uncontrolled
- Protein design
- Index Term-Uncontrolled
- RNA
- Index Term-Uncontrolled
- Scaffolds
- Added Entry-Corporate Name
- University of California, Los Angeles Biochemistry Molecular and Structural Biology 0090
- Host Item Entry
- Dissertations Abstracts International. 85-12B.
- Electronic Location and Access
- 로그인을 한후 보실 수 있는 자료입니다.
- Control Number
- joongbu:654782
MARC
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■00520250211152012
■006m o d
■007cr#unu||||||||
■020 ▼a9798382837307
■035 ▼a(MiAaPQ)AAI31331326
■040 ▼aMiAaPQ▼cMiAaPQ
■0820 ▼a574
■1001 ▼aAgdanowski, Matthew Paul.
■24510▼aProtein Nanomaterials as Tools for Cryo-EM Structural Analysis.
■260 ▼a[S.l.]▼bUniversity of California, Los Angeles. ▼c2024
■260 1▼aAnn Arbor▼bProQuest Dissertations & Theses▼c2024
■300 ▼a228 p.
■500 ▼aSource: Dissertations Abstracts International, Volume: 85-12, Section: B.
■500 ▼aAdvisor: Rodriguez, Jose Alfonso.
■5021 ▼aThesis (Ph.D.)--University of California, Los Angeles, 2024.
■520 ▼aIn the last few decades there has been tremendous technological and computational advances in the field of cryo-electron microscopy which has led to a phenomena referred to as "The Resolution Revolution," in which the number of high resolution structures solved via this technique has exploded. Despite these advances, there still remains a size limitation for your target of interest, below which high resolution microscopy remains challenging. Adding to this, a vast majority of the biologically relevant proteins and nucleic acids inside of cells lie below this size limit. Parallel advances in protein design may provide an avenue for progress on this challenging problem. By designing large protein assemblies, we are able to artificially increase the size of a given target, making it amenable to cryo-EM studies. This thesis describes recent advances in the field as well as efforts to generate imaging scaffolds for both small cancer-related protein targets, and RNA molecules. The knowledge gained through these endeavors will better guide future design efforts.
■590 ▼aSchool code: 0031.
■650 4▼aBiochemistry.
■650 4▼aOncology.
■650 4▼aGenetics.
■650 4▼aNanoscience.
■653 ▼aCryo-EM
■653 ▼aCrystallography
■653 ▼aProtein design
■653 ▼aRNA
■653 ▼aScaffolds
■690 ▼a0487
■690 ▼a0565
■690 ▼a0992
■690 ▼a0369
■71020▼aUniversity of California, Los Angeles▼bBiochemistry, Molecular and Structural Biology 0090.
■7730 ▼tDissertations Abstracts International▼g85-12B.
■790 ▼a0031
■791 ▼aPh.D.
■792 ▼a2024
■793 ▼aEnglish
■85640▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T17162438▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.
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