자료유형  

 학위논문

Control Number  

0017163380

International Standard Book Number  

9798384051817

Dewey Decimal Classification Number  

620

Main Entry-Personal Name  

Teeraratkul, Chayut.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of Colorado at Boulder., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

169 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

General Note  

Advisor: Mukherjee, Debanjan.

Dissertation Note  

Thesis (Ph.D.)--University of Colorado at Boulder, 2024.

Summary, Etc.  

요약Pathological blood clotting, or thrombosis, is the primary cause or complication in stroke and other severe cardiovascular diseases. Complications arise when a blood clot (thrombus) obstructs blood flow in key vessels. Local hemodynamics within a clot are central to clot growth, disease progression, and thrombolysis. Despite its significance, quantifying clot-flow interactions remains challenging due to the inherently multi-scale nature of realistic blood clots. At the macro-scale, pulsatile hemodynamics induce loading on a heterogeneous blood clot, resulting in a highly non-linear flow structure and clot deformation. At the micro-scale, a blood clot is an aggregate of platelets and fibrin fibers, forming a highly heterogeneous porous structure. These microstructural features play a significant role in flow-driven permeation and transport within the clot. Simultaneously resolving clot-flow interactions at both scales remains a challenge.To address these challenges, we developed novel numerical modeling methodologies that simulate clot-flow interactions while simultaneously accounting for blood clot microstructural features. In this contribution, we present our multi-scale approach to simulating blood clot-hemodynamics interactions which directly model clot microstructural features. We present two modeling strategies to account for blood clot dynamic deformation: (a) We devised a modeling strategy that couples dynamic clot deformation obtained directly from in vivo microscopy experiments. We demonstrated our proposed method on two different blood clot phenotypes, illustrating its efficacy in recovering local hemodynamics data and other flow-derived quantities that are otherwise unavailable from imaging alone; (b) We developed a two-way coupled fluid-structure interaction model that directly predict heterogeneous blood clot dynamics under pulsatile flow. We demonstrate that our model can recreate the realistic blood clot contraction behavior observed in vivo.

Subject Added Entry-Topical Term  

Fluid mechanics.

Subject Added Entry-Topical Term  

Biomechanics.

Subject Added Entry-Topical Term  

Computational physics.

Subject Added Entry-Topical Term  

Mechanical engineering.

Index Term-Uncontrolled  

Discrete Element Method

Index Term-Uncontrolled  

Blood clots

Index Term-Uncontrolled  

Fluid-structure interaction

Index Term-Uncontrolled  

Hemodynamics

Index Term-Uncontrolled  

Thrombosis

Added Entry-Corporate Name  

University of Colorado at Boulder Mechanical Engineering

Host Item Entry  

Dissertations Abstracts International. 86-03B.

Electronic Location and Access  

로그인을 한후 보실 수 있는 자료입니다.

Control Number  

joongbu:654307