자료유형  

 학위논문

Control Number  

0017161241

International Standard Book Number  

9798382815923

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Strickland, Evelyn.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, San Francisco., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

87 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Includes supplementary digital materials.

General Note  

Advisor: Weiner, Orion.

Dissertation Note  

Thesis (Ph.D.)--University of California, San Francisco, 2024.

Summary, Etc.  

요약Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves. These waves propagate through active relay in which stimulated neutrophils trigger their neighbors to release additional swarming cues. Unlike canonical active relays, we find these waves to be self-terminating, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-terminating behavior. We observe near-constant levels of neutrophil recruitment over a wide range of starting conditions, revealing surprising robustness in the swarming process. This homeostatic control is achieved by larger and more numerous swarming waves at lower cell densities. We link defective wave termination to a broken recruitment homeostat in the context of human chronic granulomatous disease.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Immunology.

Subject Added Entry-Topical Term  

Neurosciences.

Subject Added Entry-Topical Term  

Biophysics.

Index Term-Uncontrolled  

Active relay

Index Term-Uncontrolled  

Chemotaxis

Index Term-Uncontrolled  

Collective migration

Index Term-Uncontrolled  

Neutrophils

Index Term-Uncontrolled  

Swarming process

Added Entry-Corporate Name  

University of California, San Francisco Biophysics

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:654242