자료유형  

 학위논문

Control Number  

0017162711

International Standard Book Number  

9798384482406

Dewey Decimal Classification Number  

574

Main Entry-Personal Name  

Xu, Reno Jiaho.

Publication, Distribution, etc. (Imprint  

[S.l.] : University of California, Davis., 2024

Publication, Distribution, etc. (Imprint  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Physical Description  

202 p.

General Note  

Source: Dissertations Abstracts International, Volume: 86-04, Section: B.

General Note  

Advisor: Hwang, Chang-il.

Dissertation Note  

Thesis (Ph.D.)--University of California, Davis, 2024.

Summary, Etc.  

요약Pancreatic ductal adenocarcinoma (PDA) presents a significant challenge in oncology due to its aggressive nature and limited treatment options. Despite advancements in understanding the genomic landscape of PDA initiation and progression, the mechanisms driving metastasis remain elusive. This doctoral thesis explores the critical role of epigenetic mechanisms, specifically focusing on transcriptional regulation, histone modification, and molecular crowding in PDA metastasis. Through a multidisciplinary approach, encompassing genomic analyses, functional studies, and biophysical investigations, the thesis sheds light on the intricate interplay between genetic and epigenetic factors driving PDA progression. Chapters elucidate the aberrant expression of the homeodomain transcription factor EN1 in PDA, its impact on downstream signaling pathways, and its promotion of PDA transformation and metastasis. Furthermore, the thesis uncovers the influence of nucleoplasmic macromolecular crowding, particularly highlighting the role of nesprin-3, in regulating nuclear dynamics and metastatic potential in PDA. By integrating genetic, epigenetic, and biophysical perspectives, this work not only advances our understanding of PDA pathogenesis but also paves the way for the development of targeted therapeutic interventions. Additionally, the thesis underscores the significance of pancreatic cancer organoid models in recapitulating disease progression, elucidating molecular dynamics, and guiding precision medicine approaches. Overall, this research underscores the importance of a comprehensive approach in deciphering the complexities of PDA and offers valuable insights for future therapeutic strategies aimed at improving patient outcomes.

Subject Added Entry-Topical Term  

Biology.

Subject Added Entry-Topical Term  

Cellular biology.

Subject Added Entry-Topical Term  

Oncology.

Subject Added Entry-Topical Term  

Molecular biology.

Subject Added Entry-Topical Term  

Biochemistry.

Index Term-Uncontrolled  

Pancreatic ductal adenocarcinoma

Index Term-Uncontrolled  

Molecular crowding

Index Term-Uncontrolled  

Transcriptional regulations

Index Term-Uncontrolled  

Epigenetic mechanisms

Index Term-Uncontrolled  

Pancreatic cancer metastasis

Added Entry-Corporate Name  

University of California, Davis Biochemistry Molecular Cellular and Developmental Biology

Host Item Entry  

Dissertations Abstracts International. 86-04B.

Electronic Location and Access  

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Control Number  

joongbu:654214