Material Type  

 학위논문

 

0017162802

Date and Time of Latest Transaction  

20250211152056

ISBN  

9798382739151

DDC  

660

Author  

Luyet, Chloe.

Title/Author  

A Computational Characterization of Nanoscale Interactions of Biological Systems.

Publish Info  

[S.l.] : University of Michigan., 2024

Publish Info  

Ann Arbor : ProQuest Dissertations & Theses, 2024

Material Info  

127 p.

General Note  

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

General Note  

Advisor: Violi, Angela.

학위논문주기  

Thesis (Ph.D.)--University of Michigan, 2024.

Abstracts/Etc  

요약Treatment of biofilm infections is difficult, in part, due to the bacteria's pathogenicity and, in part, due to biofilm's structural resilience. Not only does a drug have to traverse the extracellular matrix, but it also has to cross membranes to be delivered to the bacterial cell. Each pathway presents a unique set of challenges. In the extracellular matrix, drugs are inhibited by networks of functional amyloid fibers, among other things. At the cellular level, drug permeation has been linked to cell membrane vibrations, which inherently depend on the composition of the membrane. Nanoparticles are a promising route for controlling biofilm growth and preventing resistance because they offer a myriad of sizes, shapes, and functional groups. In this thesis, I use molecular dynamics simulations and novel analysis methods to computationally explore the nanoscale interactions of (1) proteins, (2) membranes, and (3) nanoparticles. I characterize the structure of staphylococcal PSMα1 amyloid nanofibers, identify membrane vibrations from both eukaryotic and prokaryotic organisms, and propose interactions of chiral carbon nanoparticles with teicoplanin and phenol-soluble modulins that could be responsible for their separation by high-performance liquid chromatography and anti-biofilm capabilities, respectively. The efforts of this research have increased our understanding of nanofibers through the development of in-silico models with atomistic resolution and have helped us to screen for potential nanoparticulate candidates that could serve as biofilm manipulators.

Subject Added Entry-Topical Term  

Chemical engineering.

Subject Added Entry-Topical Term  

Microbiology.

Subject Added Entry-Topical Term  

Pathology.

Subject Added Entry-Topical Term  

Nanotechnology.

Index Term-Uncontrolled  

Functional amyloid fibers

Index Term-Uncontrolled  

Membrane vibrations

Index Term-Uncontrolled  

Anti-biofilm nanoparticles

Index Term-Uncontrolled  

Pathogenicity

Index Term-Uncontrolled  

Biofilm manipulators

Added Entry-Corporate Name  

University of Michigan Chemical Engineering

Host Item Entry  

Dissertations Abstracts International. 85-12B.

Electronic Location and Access  

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Control Number  

joongbu:653914